2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. BMS-358233

PU3 is a small molecule inhibitor of Hsp90 that competes with geldanamycin for Hsp90. PU3 induces degradation of proteins, including Her2, similar to geldanamycin. PU3 inhibits the growth of breast cancer cells, causing retinoblastoma protein hypophosphorylation, G1 arrest, and differentiation. PU3 represents a novel class of synthetic compounds that bind to Hsp90 and inhibit the proliferation of cancer cells. PU3 could provide a new strategy for the treatment of cancers.

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BMS-358233 Chemical Structure

BMS-358233 Chemical Structure

CAS No. : 601519-75-9

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BMS-358233 Related Antibodies

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Description

PU3 is a small molecule inhibitor of Hsp90 that competes with geldanamycin for Hsp90. PU3 induces degradation of proteins, including Her2, similar to geldanamycin. PU3 inhibits the growth of breast cancer cells, causing retinoblastoma protein hypophosphorylation, G1 arrest, and differentiation. PU3 represents a novel class of synthetic compounds that bind to Hsp90 and inhibit the proliferation of cancer cells. PU3 could provide a new strategy for the treatment of cancers[1].

IC50 & Target

HSP90[1]
Molecular Weight

509.02

Formula

C25H25ClN6O2S
CAS No.
SMILES

O=C(C1=CC=C2N=C(NC3=NC(NC[C@@H]4OCCC4)=NC(C)=C3)SC2=C1)NC5=C(C)C=CC=C5Cl
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMS-358233 Related Classifications

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C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-358233601519-75-9BMS358233BMS 358233HSPHeat shock proteinsInhibitorinhibitorinhibit

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