2. Anti-infection
  3. RSV
  4. BMS-433771 dihydrochloride hydrate

BMS-433771 dihydrochloride hydrate 

Cat. No.: HY-120632A Purity: 98.00%
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BMS-433771 dihydrochloride hydrate is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 dihydrochloride hydrate is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 dihydrochloride hydrate can be used for the research of respiratory tract disease.

For research use only. We do not sell to patients.

BMS-433771 dihydrochloride hydrate Chemical Structure

BMS-433771 dihydrochloride hydrate Chemical Structure

CAS No. : 543700-67-0

Size Price Stock Quantity
5 mg USD 620 In-stock
10 mg USD 770 In-stock
25 mg USD 1100 In-stock
50 mg USD 1750 In-stock
100 mg USD 2800 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of BMS-433771 dihydrochloride hydrate:

BMS-433771 dihydrochloride hydrate Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BMS-433771 dihydrochloride hydrate is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 dihydrochloride hydrate is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 dihydrochloride hydrate can be used for the research of respiratory tract disease[1][2].

IC50 & Target

EC50: 20 nM (RSV)[1]
In Vitro

BMS-433771 dihydrochloride hydrate has inhibitory against both A and B groups of RSV, with an average EC50 of 20 nM[1].
BMS-433771 dihydrochloride hydrate can inhibit viral F protein-induced membrane fusion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-433771 dihydrochloride hydrate Related Antibodies
In Vivo

BMS-433771 dihydrochloride hydrate (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing，but has considerable pharmacodynamic differences between the two rodent models[2]
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

468.38

Formula

C21H27Cl2N5O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1C2CC2)N(CC3=NC4=CC=CC=C4N3CCCCO)C5=C1C=CN=C5.[H]Cl.[H]Cl.[H]O[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (106.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1350 mL 10.6751 mL 21.3502 mL
5 mM 0.4270 mL 2.1350 mL 4.2700 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1350 mL 10.6751 mL 21.3502 mL 53.3755 mL
5 mM 0.4270 mL 2.1350 mL 4.2700 mL 10.6751 mL
10 mM 0.2135 mL 1.0675 mL 2.1350 mL 5.3375 mL
15 mM 0.1423 mL 0.7117 mL 1.4233 mL 3.5584 mL
20 mM 0.1068 mL 0.5338 mL 1.0675 mL 2.6688 mL
25 mM 0.0854 mL 0.4270 mL 0.8540 mL 2.1350 mL
30 mM 0.0712 mL 0.3558 mL 0.7117 mL 1.7792 mL
40 mM 0.0534 mL 0.2669 mL 0.5338 mL 1.3344 mL
50 mM 0.0427 mL 0.2135 mL 0.4270 mL 1.0675 mL
60 mM 0.0356 mL 0.1779 mL 0.3558 mL 0.8896 mL
80 mM 0.0267 mL 0.1334 mL 0.2669 mL 0.6672 mL
100 mM 0.0214 mL 0.1068 mL 0.2135 mL 0.5338 mL
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BMS-433771 dihydrochloride hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-433771 dihydrochloride543700-67-0RSVRespiratory syncytial virusrespiratory syncytial virus (RSV)oralrespiratory tract diseaseviral Fmembrane fusionInhibitorinhibitorinhibit

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