BMS-901715

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BMS-901715 is a potent and selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC₅₀ of 3.3 nM.

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BMS-901715 Chemical Structure

CAS No. : 1699861-37-4

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Description	BMS-901715 is a potent and selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC₅₀ of 3.3 nM^[1]^[2].
IC₅₀ & Target	IC50: 3.3 nM (Adapter protein-2 associated kinase 1 (AAK1))^[2]
In Vitro	Adaptor associated kinase 1 (AAK1) is a member of the Ark1/Prk1 family of serine/threonine kinases. AAK1 mRNA exists in two splice forms termed short and long. The long form predominates and is highly expressed in brain and heart. AAK1 is enriched in synaptosomal preparations and is co-localized with endocytic structures in cultured cells. AAK1 modulates clatherin coated endocytosis, a process that is important in synaptic vesicle recycling and receptor-mediated endocytosis^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. BMS-901715 Related Antibodies
Molecular Weight	448.52
Formula	C₂₂H₂₈N₁₀O
CAS No.	1699861-37-4
SMILES	OC1=CC(C2=NN(C(C)C)N=N2)=CC(NC3=NC=NN4C3=C(CN5CCC(N)CC5)C=C4)=C1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86. [Content Brief] [2]. Carolyn Diane Dzierba, et al. Pyrrolotriazine kinase inhibitors. WO2015054358A1.

BMS-901715 Related Classifications

Neurological Disease

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C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-9017151699861-37-4BMS901715BMS 901715AAK1Adaptor-associated Kinase 1AP2-associated kinase 1potentInhibitorinhibitorinhibit

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BMS-901715

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