2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. BMT-297376

BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.

For research use only. We do not sell to patients.

BMT-297376 Chemical Structure

BMT-297376 Chemical Structure

CAS No. : 2251031-81-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1025 In-stock
Solution
10 mM * 1 mL in DMSO USD 1025 In-stock
Solid
1 mg USD 470 In-stock
5 mg USD 1075 In-stock
10 mg USD 1720 In-stock
25 mg USD 3372 In-stock
50 mg USD 5160 In-stock
100 mg USD 7222 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Customer Review

Based on 1 publication(s) in Google Scholar

BMT-297376 Related Antibodies

Top Publications Citing Use of Products

View All Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

View All Isoforms
IDO1 IDO2 IDO

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor[1].

Molecular Weight

433.49

Formula

C23H29F2N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(C1=C(OC)N=CC=C1[C@H]2CC[C@@](CC2)([H])[C@@H](CC)NC(C3=CN=C(OC)C=C3)=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : ≥ 100 mg/mL (230.69 mM)

DMSO : 100 mg/mL (230.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3069 mL 11.5343 mL 23.0686 mL
5 mM 0.4614 mL 2.3069 mL 4.6137 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol / DMSO 1 mM 2.3069 mL 11.5343 mL 23.0686 mL 57.6715 mL
5 mM 0.4614 mL 2.3069 mL 4.6137 mL 11.5343 mL
10 mM 0.2307 mL 1.1534 mL 2.3069 mL 5.7671 mL
15 mM 0.1538 mL 0.7690 mL 1.5379 mL 3.8448 mL
20 mM 0.1153 mL 0.5767 mL 1.1534 mL 2.8836 mL
25 mM 0.0923 mL 0.4614 mL 0.9227 mL 2.3069 mL
30 mM 0.0769 mL 0.3845 mL 0.7690 mL 1.9224 mL
40 mM 0.0577 mL 0.2884 mL 0.5767 mL 1.4418 mL
50 mM 0.0461 mL 0.2307 mL 0.4614 mL 1.1534 mL
60 mM 0.0384 mL 0.1922 mL 0.3845 mL 0.9612 mL
80 mM 0.0288 mL 0.1442 mL 0.2884 mL 0.7209 mL
100 mM 0.0231 mL 0.1153 mL 0.2307 mL 0.5767 mL
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BMT-297376 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMT-2973762251031-81-7BMT297376BMT 297376Indoleamine 2,3-Dioxygenase (IDO)Inhibitorinhibitorinhibit

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