BMY 45778

Cat. No.: HY-108565 Purity: 98.98%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC₅₀ = 35 nM), rabbit (IC₅₀: 136 nM) and rat (IC₅₀ : 1.3 μM) platelet aggregation. BMY 45778 also activates adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor.

For research use only. We do not sell to patients.

BMY 45778 Chemical Structure

CAS No. : 152575-66-1

Size	Price	Stock
5 mg		Ask For Quote & Lead Time
10 mg		Ask For Quote & Lead Time
25 mg		Ask For Quote & Lead Time
50 mg		Ask For Quote & Lead Time
100 mg		Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

438.43

Formula

C₂₆H₁₈N₂O₅

CAS No.

152575-66-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)COC1=CC=CC(C2=C(C3=NC(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)N=CO2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (114.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2809 mL	11.4043 mL	22.8087 mL
5 mM	0.4562 mL	2.2809 mL	4.5617 mL
10 mM	0.2281 mL	1.1404 mL	2.2809 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.98%

Select Batch:

Data Sheet (280 KB) SDS (251 KB)

COA (262 KB) HNMR (266 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Seiler SM, et al. [3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and iloprost binding. Prostaglandins. 1997 Jan;53(1):21-35. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2809 mL	11.4043 mL	22.8087 mL	57.0216 mL
	5 mM	0.4562 mL	2.2809 mL	4.5617 mL	11.4043 mL
	10 mM	0.2281 mL	1.1404 mL	2.2809 mL	5.7022 mL
	15 mM	0.1521 mL	0.7603 mL	1.5206 mL	3.8014 mL
	20 mM	0.1140 mL	0.5702 mL	1.1404 mL	2.8511 mL
	25 mM	0.0912 mL	0.4562 mL	0.9123 mL	2.2809 mL
	30 mM	0.0760 mL	0.3801 mL	0.7603 mL	1.9007 mL
	40 mM	0.0570 mL	0.2851 mL	0.5702 mL	1.4255 mL
	50 mM	0.0456 mL	0.2281 mL	0.4562 mL	1.1404 mL
	60 mM	0.0380 mL	0.1901 mL	0.3801 mL	0.9504 mL
	80 mM	0.0285 mL	0.1426 mL	0.2851 mL	0.7128 mL
	100 mM	0.0228 mL	0.1140 mL	0.2281 mL	0.5702 mL

BMY 45778 Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMY 45778152575-66-1BMY45778BMY-45778Adenylate CyclaseProstaglandin ReceptorAdenylyl cyclaseplateletaggregationprostacyclin mimeticInhibitorinhibitorinhibit

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