2. PROTAC
  3. PROTAC Linkers
  4. Boc-C1-PEG3-C4-OBn

Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1 (HY-125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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Boc-C1-PEG3-C4-OBn Chemical Structure

Boc-C1-PEG3-C4-OBn Chemical Structure

CAS No. : 2381196-81-0

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50 mg USD 110 In-stock
100 mg USD 180 In-stock
250 mg USD 350 In-stock
500 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

Boc-C1-PEG3-C4-OBn Related Antibodies

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1 (HY-125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC50 & Target[1]

PEGs

 

Alkyl/ether

 

Molecular Weight

410.54

Formula

C23H38O6
CAS No.
Appearance

Liquid (Density: 1.029 g/cm3)

Color

Light yellow to yellow

SMILES

O=C(OC(C)(C)C)COCCOCCOCCCCCCOCC1=CC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (243.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4358 mL 12.1791 mL 24.3582 mL
5 mM 0.4872 mL 2.4358 mL 4.8716 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4358 mL 12.1791 mL 24.3582 mL 60.8954 mL
5 mM 0.4872 mL 2.4358 mL 4.8716 mL 12.1791 mL
10 mM 0.2436 mL 1.2179 mL 2.4358 mL 6.0895 mL
15 mM 0.1624 mL 0.8119 mL 1.6239 mL 4.0597 mL
20 mM 0.1218 mL 0.6090 mL 1.2179 mL 3.0448 mL
25 mM 0.0974 mL 0.4872 mL 0.9743 mL 2.4358 mL
30 mM 0.0812 mL 0.4060 mL 0.8119 mL 2.0298 mL
40 mM 0.0609 mL 0.3045 mL 0.6090 mL 1.5224 mL
50 mM 0.0487 mL 0.2436 mL 0.4872 mL 1.2179 mL
60 mM 0.0406 mL 0.2030 mL 0.4060 mL 1.0149 mL
80 mM 0.0304 mL 0.1522 mL 0.3045 mL 0.7612 mL
100 mM 0.0244 mL 0.1218 mL 0.2436 mL 0.6090 mL
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Boc-C1-PEG3-C4-OBn Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-C1-PEG3-C4-OBn2381196-81-0PROTAC LinkersPROTAClinkerPEGInhibitorinhibitorinhibit

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