2. PROTAC
  3. PROTAC Linkers
  4. Boc-GABA-OH

Boc-GABA-OH is a PROTAC linker which can be used to synthesis UNC6852, an EED-targeted PROTAC.

For research use only. We do not sell to patients.

Boc-GABA-OH Chemical Structure

Boc-GABA-OH Chemical Structure

CAS No. : 57294-38-9

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Based on 1 publication(s) in Google Scholar

Boc-GABA-OH Related Antibodies

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Description

Boc-GABA-OH is a PROTAC linker which can be used to synthesis UNC6852, an EED-targeted PROTAC[1].

IC50 & Target

Alkyl/ether

 

Molecular Weight

203.24

Formula

C9H17NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCCNC(OC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (492.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9203 mL 24.6015 mL 49.2029 mL
5 mM 0.9841 mL 4.9203 mL 9.8406 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (243 KB) HNMR (223 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9203 mL 24.6015 mL 49.2029 mL 123.0073 mL
5 mM 0.9841 mL 4.9203 mL 9.8406 mL 24.6015 mL
10 mM 0.4920 mL 2.4601 mL 4.9203 mL 12.3007 mL
15 mM 0.3280 mL 1.6401 mL 3.2802 mL 8.2005 mL
20 mM 0.2460 mL 1.2301 mL 2.4601 mL 6.1504 mL
25 mM 0.1968 mL 0.9841 mL 1.9681 mL 4.9203 mL
30 mM 0.1640 mL 0.8200 mL 1.6401 mL 4.1002 mL
40 mM 0.1230 mL 0.6150 mL 1.2301 mL 3.0752 mL
50 mM 0.0984 mL 0.4920 mL 0.9841 mL 2.4601 mL
60 mM 0.0820 mL 0.4100 mL 0.8200 mL 2.0501 mL
80 mM 0.0615 mL 0.3075 mL 0.6150 mL 1.5376 mL
100 mM 0.0492 mL 0.2460 mL 0.4920 mL 1.2301 mL
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Boc-GABA-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-GABA-OH57294-38-9PROTAC LinkersUNC6852EED-targetedInhibitorinhibitorinhibit

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