2. Cytoskeleton
  3. Integrin
  4. BOP sodium

BOP sodium is a potent and selective dual α9β1/α4β1 integrin inhibitor with Kd values in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP sodium has little inhibitory activity on α4β7, α1β1, α2β1, and α5β1, αIIBβ3 integrins.

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BOP sodium Chemical Structure

BOP sodium Chemical Structure

CAS No. : 1947348-42-6

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5 mg USD 695 In-stock
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Based on 1 publication(s) in Google Scholar

BOP sodium Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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  • Purity & Documentation

  • References

  • Customer Review

Description

BOP sodium is a potent and selective dual α9β1/α4β1 integrin inhibitor with Kd values in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP sodium has little inhibitory activity on α4β7, α1β1, α2β1, and α5β1, αIIBβ3 integrins[1][2].

IC50 & Target[1][2]

α4β1

 

α9β1

 

Molecular Weight

537.56

Formula

C25H28N3NaO7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])[C@H](CC1=CC=C(OC(N2CCCC2)=O)C=C1)NC([C@H]3N(S(=O)(C4=CC=CC=C4)=O)CCC3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (232.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8603 mL 9.3013 mL 18.6026 mL
5 mM 0.3721 mL 1.8603 mL 3.7205 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.11%

SDS (251 KB)

COA (256 KB) HNMR (141 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8603 mL 9.3013 mL 18.6026 mL 46.5064 mL
5 mM 0.3721 mL 1.8603 mL 3.7205 mL 9.3013 mL
10 mM 0.1860 mL 0.9301 mL 1.8603 mL 4.6506 mL
15 mM 0.1240 mL 0.6201 mL 1.2402 mL 3.1004 mL
20 mM 0.0930 mL 0.4651 mL 0.9301 mL 2.3253 mL
25 mM 0.0744 mL 0.3721 mL 0.7441 mL 1.8603 mL
30 mM 0.0620 mL 0.3100 mL 0.6201 mL 1.5502 mL
40 mM 0.0465 mL 0.2325 mL 0.4651 mL 1.1627 mL
50 mM 0.0372 mL 0.1860 mL 0.3721 mL 0.9301 mL
60 mM 0.0310 mL 0.1550 mL 0.3100 mL 0.7751 mL
80 mM 0.0233 mL 0.1163 mL 0.2325 mL 0.5813 mL
100 mM 0.0186 mL 0.0930 mL 0.1860 mL 0.4651 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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BOP sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BOP1947348-42-6Integrinα9β1α4β1integrinHSCprogenitorsmobilizationInhibitorinhibitorinhibit

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