Bortezomib-d₈ (Synonyms: PS-341-d₈; LDP-341-d₈; NSC 681239-d₈)

Name: Bortezomib-d 8
Brand: MedChemExpress
SKU: HY-10227S
Rating: 4.5 (1 reviews)

Cat. No.: HY-10227S Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity[1][2].

For research use only. We do not sell to patients.

Bortezomib-d<sub>8</sub> Chemical Structure

Bortezomib-d₈ Chemical Structure

Size	Price	Stock	Quantity
100 μg	USD 150	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 750	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

392.29

Formula

C₁₉H₁₇D₈BN₄O₄

Unlabeled CAS

179324-69-7

Appearance

Solid

Color

White to off-white

SMILES

OB([C@H](CC(C)C)NC(C(NC(C1=NC=CN=C1)=O)([2H])C([2H])([2H])C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

Ethanol : 66.67 mg/mL (169.95 mM; ultrasonic and warming and heat to 60°C)

DMSO : 50 mg/mL (127.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5491 mL	12.7457 mL	25.4913 mL
5 mM	0.5098 mL	2.5491 mL	5.0983 mL
10 mM	0.2549 mL	1.2746 mL	2.5491 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (279 KB) SDS (251 KB)

COA (256 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Adams J, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999 Jun 1;59(11):2615-22. [Content Brief]

[3]. Shahshahan MA, et al. Potential usage of proteasome inhibitor bortezomib (Velcade, PS-341) in the treatment of metastaticmelanoma: basic and clinical aspects. Am J Cancer Res. 2011;1(7):913-24. [Content Brief]

[4]. Pérez-Galán P, et al. The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood. 2006 Jan 1;107(1):257-64. [Content Brief]

[5]. Yerlikaya A, et al. Combined effects of the proteasome inhibitor bortezomib and Hsp70 inhibitors on the B16F10 melanoma cell line. Mol Med Rep. 2010 Mar-Apr;3(2):333-9. [Content Brief]

[6]. Mujtaba T, et al. Advances in the understanding of mechanisms and therapeutic use of bortezomib. Discov Med. 2011 Dec;12(67):471-80. [Content Brief]

[7]. Fernández Y, et al. Chemical blockage of the proteasome inhibitory function of bortezomib: impact on tumor cell death. J Biol Chem. 2006 Jan 13;281(2):1107-18. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO / Ethanol / Ethanol	1 mM	2.5491 mL	12.7457 mL	25.4913 mL	63.7284 mL
	5 mM	0.5098 mL	2.5491 mL	5.0983 mL	12.7457 mL
	10 mM	0.2549 mL	1.2746 mL	2.5491 mL	6.3728 mL
	15 mM	0.1699 mL	0.8497 mL	1.6994 mL	4.2486 mL
	20 mM	0.1275 mL	0.6373 mL	1.2746 mL	3.1864 mL
	25 mM	0.1020 mL	0.5098 mL	1.0197 mL	2.5491 mL
	30 mM	0.0850 mL	0.4249 mL	0.8497 mL	2.1243 mL
	40 mM	0.0637 mL	0.3186 mL	0.6373 mL	1.5932 mL
	50 mM	0.0510 mL	0.2549 mL	0.5098 mL	1.2746 mL
	60 mM	0.0425 mL	0.2124 mL	0.4249 mL	1.0621 mL
	80 mM	0.0319 mL	0.1593 mL	0.3186 mL	0.7966 mL
	100 mM	0.0255 mL	0.1275 mL	0.2549 mL	0.6373 mL

Bortezomib-d₈ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bortezomib-d₈PS-341-d₈LDP-341-d₈NSC 681239-d₈ProteasomeNF-κBApoptosisAutophagyNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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Bortezomib-d8 (Synonyms: PS-341-d8; LDP-341-d8; NSC 681239-d8)

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Complete Stock Solution Preparation Table

Bortezomib-d8 Related Classifications

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Bortezomib-d₈ (Synonyms: PS-341-d₈; LDP-341-d₈; NSC 681239-d₈)

Other Forms of Bortezomib-d₈:

Bortezomib-d₈ Related Antibodies

Bortezomib-d₈ Related Antibodies

Bortezomib-d₈ Related Classifications