BP-1-108

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BP-1-108 is a selective inhibitor of STAT5 (K_i=8.3 μM) with anticancer activity. BP-1-108 induces apoptosis of leukemia cells by inhibiting the phosphorylation of STAT5. BP-1-108 can be used in the study of acute myeloid leukemia and prostate cancer.

For research use only. We do not sell to patients.

BP-1-108 Chemical Structure

CAS No. : 1334492-85-1

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STAT3 STAT5 STAT6 STAT1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

STAT5

8.3 μM (Ki)

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	42 μM Compound: BP-1-108	Cytotoxicity against human K562 cells expressing STAT5 after 48 hrs by alamar blue fluorescent staining Cytotoxicity against human K562 cells expressing STAT5 after 48 hrs by alamar blue fluorescent staining	[PMID: 22148584]
MV4-11	IC₅₀	17 μM Compound: BP-1-108	Cytotoxicity against human MV4-11 cells expressing STAT5 after 48 hrs by alamar blue fluorescent staining Cytotoxicity against human MV4-11 cells expressing STAT5 after 48 hrs by alamar blue fluorescent staining	[PMID: 22148584]
NIH3T3	IC₅₀	100 μM Compound: BP-1-108	Disruption of preformed STAT5 homodimer in NIH3T3 cells co-expressing human EGFR nuclear extracts by electrophoretic mobility shift assay Disruption of preformed STAT5 homodimer in NIH3T3 cells co-expressing human EGFR nuclear extracts by electrophoretic mobility shift assay	[PMID: 22148584]

Molecular Weight

578.72

Formula

C₃₂H₃₈N₂O₆S

CAS No.

1334492-85-1

SMILES

O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(C)C=C(C)C=C4C)=O)=O)C=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Page, et al. "Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity." Journal of medicinal chemistry 55.3 (2012): 1047-1055. [Content Brief]

BP-1-108 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BP-1-1081334492-85-1STATApoptosisinhibitorphosphorylationleukemiaprostate cancerInhibitorinhibit

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