2. Membrane Transporter/Ion Channel
  3. HCN Channel
  4. BPU-11

BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease.

For research use only. We do not sell to patients.

BPU-11 Chemical Structure

BPU-11 Chemical Structure

CAS No. : 909664-41-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 99 In-stock
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Solid
5 mg USD 90 In-stock
10 mg USD 150 In-stock
25 mg USD 270 In-stock
50 mg USD 430 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

BPU-11 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease[1].

In Vitro

BPU-11 (100 μM) abolishes the HCN4 cAMP-induced shift in V1/2 with a k1/2 of 0.42 μM[1].
BPU (100 and 200 μM) is specific of the HCN4 isoform and shows no effect on human HCN2 channels expressed in HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BPU-11 Related Antibodies
Molecular Weight

501.62

Formula

C32H31N5O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N(CC1=CC=CN=C1)C2CCN(CC2)CC3=CC=CC(C#N)=C3)NC4=CC=CC=C4C5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (249.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9935 mL 9.9677 mL 19.9354 mL
5 mM 0.3987 mL 1.9935 mL 3.9871 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9935 mL 9.9677 mL 19.9354 mL 49.8385 mL
5 mM 0.3987 mL 1.9935 mL 3.9871 mL 9.9677 mL
10 mM 0.1994 mL 0.9968 mL 1.9935 mL 4.9839 mL
15 mM 0.1329 mL 0.6645 mL 1.3290 mL 3.3226 mL
20 mM 0.0997 mL 0.4984 mL 0.9968 mL 2.4919 mL
25 mM 0.0797 mL 0.3987 mL 0.7974 mL 1.9935 mL
30 mM 0.0665 mL 0.3323 mL 0.6645 mL 1.6613 mL
40 mM 0.0498 mL 0.2492 mL 0.4984 mL 1.2460 mL
50 mM 0.0399 mL 0.1994 mL 0.3987 mL 0.9968 mL
60 mM 0.0332 mL 0.1661 mL 0.3323 mL 0.8306 mL
80 mM 0.0249 mL 0.1246 mL 0.2492 mL 0.6230 mL
100 mM 0.0199 mL 0.0997 mL 0.1994 mL 0.4984 mL
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BPU-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPU-11909664-41-1BPU11BPU 11HCN ChannelHyperpolarization activated cyclic nucleotide gated channelsligandheart rateC-linker pocketHEK293TInhibitorinhibitorinhibit

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