BQ-3020 

BQ-3020 is a selective endothelin receptor (ET_B receptor) agonist that displaces [¹²⁵I] ET-1 binding to ET_B receptors, with an IC₅₀ value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research¹².

BQ-3020 (0.01–300 nM, 7 min), produced concentration-dependent relaxationso on PhE-precontracted urothelium-denuded strips^[1].
BQ-3020 (0.01–200 nM, 20 min) causes potent dose-dependent vasoconstriction with EC₅₀ values of 0.57nM in rabbit pulmonary arteries by inhibiting ETB receptors^[2].
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BQ-3020 (3 mg/kg for i.h., single dose) attenuates cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection in cancer pain mouse model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2006.32

C₉₆H₁₄₀N₂₀O₂₅S

143113-45-5

Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp

Ac-Acetyl-LMDKEAVYFAHLDIIW

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Arteaga JL,et.al. Endothelin ET(B) receptors are involved in the relaxation to the pig urinary bladder neck. Neurourol Urodyn. 2012 Jun;31(5):688-94.  [Content Brief]

  [2]. Ihara M, et.al. A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors. Life Sci. 1992;51(6):PL47-52.  [Content Brief]

  [3]. Quang PN, et.al. Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice. Pain. 2010 May;149(2):254-262.  [Content Brief]