2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. BR-cpd7

BR-cpd7 is a PROTAC degrader for fibroblast growth factor receptor FGFR1/2 with DC50 of 10 nM. BR-cpd7 arrests cell cycle, inhibits proliferations of FGFR1/2 aberrant activated tumor cells. (Pink: ligand for target protein FGFR-IN-12 (HY-160013); Black: linker; Blue: ligand for E3 ligase Thalidomide-NH-CH2-COOH (HY-131717))

For research use only. We do not sell to patients.

BR-cpd7 Chemical Structure

BR-cpd7 Chemical Structure

Size Price Stock Quantity
1 mg USD 465 In-stock
5 mg USD 1160 In-stock
10 mg USD 1860 In-stock
25 mg USD 3720 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

BR-cpd7 Related Antibodies

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

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Description

BR-cpd7 is a PROTAC degrader for fibroblast growth factor receptor FGFR1/2 with DC50 of 10 nM. BR-cpd7 arrests cell cycle, inhibits proliferations of FGFR1/2 aberrant activated tumor cells. (Pink: ligand for target protein FGFR-IN-12 (HY-160013); Black: linker; Blue: ligand for E3 ligase Thalidomide-NH-CH2-COOH (HY-131717))[1]

Molecular Weight

928.82

Formula

C44H47Cl2N11O8
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=CC(OC)=C(C(NC(N(C2=CC(NC3=CC=C(C=C3)N4CCN(CC4)C5CCN(CC5)C(CNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=O)=NC=N2)C)=O)=C1Cl)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (107.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0766 mL 5.3832 mL 10.7663 mL
5 mM 0.2153 mL 1.0766 mL 2.1533 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0766 mL 5.3832 mL 10.7663 mL 26.9159 mL
5 mM 0.2153 mL 1.0766 mL 2.1533 mL 5.3832 mL
10 mM 0.1077 mL 0.5383 mL 1.0766 mL 2.6916 mL
15 mM 0.0718 mL 0.3589 mL 0.7178 mL 1.7944 mL
20 mM 0.0538 mL 0.2692 mL 0.5383 mL 1.3458 mL
25 mM 0.0431 mL 0.2153 mL 0.4307 mL 1.0766 mL
30 mM 0.0359 mL 0.1794 mL 0.3589 mL 0.8972 mL
40 mM 0.0269 mL 0.1346 mL 0.2692 mL 0.6729 mL
50 mM 0.0215 mL 0.1077 mL 0.2153 mL 0.5383 mL
60 mM 0.0179 mL 0.0897 mL 0.1794 mL 0.4486 mL
80 mM 0.0135 mL 0.0673 mL 0.1346 mL 0.3364 mL
100 mM 0.0108 mL 0.0538 mL 0.1077 mL 0.2692 mL
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BR-cpd7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BR-cpd7FGFRFibroblast growth factor receptorisoform specificitylung cancerInhibitorinhibitorinhibit

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