2. PROTAC
  3. PROTAC Linkers
  4. Br-PEG3-C2-Boc

Br-PEG3-C2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Br-PEG3-C2-Boc Chemical Structure

Br-PEG3-C2-Boc Chemical Structure

CAS No. : 782475-37-0

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100 mg USD 140 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Br-PEG3-C2-Boc Related Antibodies

Top Publications Citing Use of Products

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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  • Purity & Documentation

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Description

Br-PEG3-C2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Br-PEG3-C2-Boc Related Antibodies
Molecular Weight

341.24

Formula

C13H25BrO5
CAS No.
Appearance

Liquid (Density: 1.223±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCOCCOCCBr
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (293.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9305 mL 14.6524 mL 29.3049 mL
5 mM 0.5861 mL 2.9305 mL 5.8610 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

COA (240 KB) HNMR (118 KB) MS (152 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9305 mL 14.6524 mL 29.3049 mL 73.2622 mL
5 mM 0.5861 mL 2.9305 mL 5.8610 mL 14.6524 mL
10 mM 0.2930 mL 1.4652 mL 2.9305 mL 7.3262 mL
15 mM 0.1954 mL 0.9768 mL 1.9537 mL 4.8841 mL
20 mM 0.1465 mL 0.7326 mL 1.4652 mL 3.6631 mL
25 mM 0.1172 mL 0.5861 mL 1.1722 mL 2.9305 mL
30 mM 0.0977 mL 0.4884 mL 0.9768 mL 2.4421 mL
40 mM 0.0733 mL 0.3663 mL 0.7326 mL 1.8316 mL
50 mM 0.0586 mL 0.2930 mL 0.5861 mL 1.4652 mL
60 mM 0.0488 mL 0.2442 mL 0.4884 mL 1.2210 mL
80 mM 0.0366 mL 0.1832 mL 0.3663 mL 0.9158 mL
100 mM 0.0293 mL 0.1465 mL 0.2930 mL 0.7326 mL
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Br-PEG3-C2-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Br-PEG3-C2-Boc782475-37-0PROTAC LinkersInhibitorinhibitorinhibit

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