2. PROTAC
  3. PROTAC Linkers
  4. Br-PEG4-OH

Br-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Br-PEG4-OH Chemical Structure

Br-PEG4-OH Chemical Structure

CAS No. : 85141-94-2

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5 g USD 204 In-stock
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Based on 1 publication(s) in Google Scholar

Br-PEG4-OH Related Antibodies

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  • Purity & Documentation

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Description

Br-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Br-PEG4-OH Related Antibodies
Molecular Weight

257.12

Formula

C8H17BrO4
CAS No.
Appearance

Liquid (Density: 1.350±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

BrCCOCCOCCOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (388.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8892 mL 19.4462 mL 38.8923 mL
5 mM 0.7778 mL 3.8892 mL 7.7785 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.73%

COA (239 KB) HNMR (130 KB) GC (215 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8892 mL 19.4462 mL 38.8923 mL 97.2309 mL
5 mM 0.7778 mL 3.8892 mL 7.7785 mL 19.4462 mL
10 mM 0.3889 mL 1.9446 mL 3.8892 mL 9.7231 mL
15 mM 0.2593 mL 1.2964 mL 2.5928 mL 6.4821 mL
20 mM 0.1945 mL 0.9723 mL 1.9446 mL 4.8615 mL
25 mM 0.1556 mL 0.7778 mL 1.5557 mL 3.8892 mL
30 mM 0.1296 mL 0.6482 mL 1.2964 mL 3.2410 mL
40 mM 0.0972 mL 0.4862 mL 0.9723 mL 2.4308 mL
50 mM 0.0778 mL 0.3889 mL 0.7778 mL 1.9446 mL
60 mM 0.0648 mL 0.3241 mL 0.6482 mL 1.6205 mL
80 mM 0.0486 mL 0.2431 mL 0.4862 mL 1.2154 mL
100 mM 0.0389 mL 0.1945 mL 0.3889 mL 0.9723 mL
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Br-PEG4-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Br-PEG4-OH85141-94-2PROTAC LinkersInhibitorinhibitorinhibit

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