2. MAPK/ERK Pathway Cell Cycle/DNA Damage Immunology/Inflammation
  3. JNK PERK MEK NO Synthase
  4. BRAFV600E/JNK-IN-1

BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3 and BRAFV600E, with IC50 values of 0.51 μM, 0.53 μM, 1.02 μM and 0.009 μM, respectively. BRAFV600E/JNK-IN-1 can inhibit the phosphorylation of MEK1/2 and ERK1/2. In addition, BRAFV600E/JNK-IN-1 can inhibit tumor cell proliferation, NO release and PGE2 production, and has anti-tumor and anti-inflammatory activities.

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BRAFV600E/JNK-IN-1 Chemical Structure

BRAFV600E/JNK-IN-1 Chemical Structure

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BRAFV600E/JNK-IN-1 Related Antibodies

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Description

BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3 and BRAFV600E, with IC50 values of 0.51 μM, 0.53 μM, 1.02 μM and 0.009 μM, respectively. BRAFV600E/JNK-IN-1 can inhibit the phosphorylation of MEK1/2 and ERK1/2. In addition, BRAFV600E/JNK-IN-1 can inhibit tumor cell proliferation, NO release and PGE2 production, and has anti-tumor and anti-inflammatory activities[1].

Molecular Weight

513.01

Formula

C24H25ClN6O3S
SMILES

OC1=CC(C2=NN(CC)C=C2C3=CC=NC(NCCCNS(=O)(C4=CC=C(Cl)C=C4)=O)=N3)=CC=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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BRAFV600E/JNK-IN-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRAFV600E/JNK-IN-1JNKPERKMEKNO Synthasec-Jun N-terminal kinaseProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseMitogen-activated protein kinase kinaseMAPKKMAP2KNitric oxide synthasesNOSMOLT-4K-562SK-MEL-28A375RAW 264.7Inhibitorinhibitorinhibit

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