2. Immunology/Inflammation
  3. Interleukin Related
  4. Brazikumab

Brazikumab  (Synonyms: AMG 139; MEDI2070)

Cat. No.: HY-P99485 Purity: 95.00%
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Brazikumab (AMG 139) is a human IgG2 monoclonal antibody, selectively binds the p19 subunit of IL-23, with a KD of 0.138 nM for human IL-23. Brazikumab can be used for the research of Crohn's disease.

For research use only. We do not sell to patients.

CAS No. : 1610353-18-8

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Based on 1 publication(s) in Google Scholar

Brazikumab Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

Brazikumab (AMG 139) is a human IgG2 monoclonal antibody, selectively binds the p19 subunit of IL-23, with a KD of 0.138 nM for human IL-23. Brazikumab can be used for the research of Crohn's disease[1].

Isotype

Human IgG2
Recommend Isotype Controls
Species

Human
IC50 & Target[1]

IL-23

0.138 nM (Kd)

In Vitro

Brazikumab inhibits the binding of both recombinant and native IL-23 to its receptors stably expressed in COS cells with IC50s of 188 and 284 pM, respectively[1].
Brazikumab inhibits the production of IFN-γ in NK cells stimulated by human native or recombinant IL-23 (in association with IL-18) with IC50s of 238 and 93 pM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Brazikumab Related Antibodies
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Brazikumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 lambda
Purity & Documentation
References
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Brazikumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Brazikumab1610353-18-8AMG 139 MEDI2070AMG139AMG-139MEDI2070MEDI 2070MEDI-2070Interleukin RelatedILp19IL-23Crohn's diseaseInhibitorinhibitorinhibit

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