2. Apoptosis
  3. Caspase
  4. BRD-810

BRD-810 is a highly selective MCL1 inhibitor. BRD-810 can bind to the BH3 groove of MCL1 and block the sequestration of pro-apoptotic proteins, quickly inducing caspase activation in MCL1-dependent cell lines. BRD-810 shows anti-tumor activity in models of blood cancers and solid tumors.

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BRD-810 Chemical Structure

BRD-810 Chemical Structure

CAS No. : 2329719-65-3

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Based on 1 publication(s) in Google Scholar

BRD-810 Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

BRD-810 is a highly selective MCL1 inhibitor. BRD-810 can bind to the BH3 groove of MCL1 and block the sequestration of pro-apoptotic proteins, quickly inducing caspase activation in MCL1-dependent cell lines. BRD-810 shows anti-tumor activity in models of blood cancers and solid tumors[1].
Molecular Weight

703.24

Formula

C39H44ClFN4O5
CAS No.
Appearance

Solid

SMILES

O=C(O)C(N1CCCCO[C@H](CCN2CCOCC2)C3=NN(C)C(CC)=C43)=C(CCCOC5=C6C(C=C(F)C=C6)=CC=C5)C7=C1C4=C(Cl)C=C7
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (142.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4220 mL 7.1099 mL 14.2199 mL
5 mM 0.2844 mL 1.4220 mL 2.8440 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4220 mL 7.1099 mL 14.2199 mL 35.5497 mL
5 mM 0.2844 mL 1.4220 mL 2.8440 mL 7.1099 mL
10 mM 0.1422 mL 0.7110 mL 1.4220 mL 3.5550 mL
15 mM 0.0948 mL 0.4740 mL 0.9480 mL 2.3700 mL
20 mM 0.0711 mL 0.3555 mL 0.7110 mL 1.7775 mL
25 mM 0.0569 mL 0.2844 mL 0.5688 mL 1.4220 mL
30 mM 0.0474 mL 0.2370 mL 0.4740 mL 1.1850 mL
40 mM 0.0355 mL 0.1777 mL 0.3555 mL 0.8887 mL
50 mM 0.0284 mL 0.1422 mL 0.2844 mL 0.7110 mL
60 mM 0.0237 mL 0.1185 mL 0.2370 mL 0.5925 mL
80 mM 0.0178 mL 0.0889 mL 0.1777 mL 0.4444 mL
100 mM 0.0142 mL 0.0711 mL 0.1422 mL 0.3555 mL
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BRD-810 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD-8102329719-65-3BRD810BRD 810CaspaseMCL1BH3caspaseblood cancersolid tumorInhibitorinhibitorinhibit

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