2. Epigenetics Apoptosis
  3. Epigenetic Reader Domain Apoptosis Bcl-2 Family Caspase c-Myc
  4. BRD4 Inhibitor-15

BRD4 Inhibitor-15 (compound 13) is a potent BRD4 inhibitor, with an IC50 of 18 nM. BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling pathway. BRD4 Inhibitor-15 down-regulates the c-Myc level in 22RV1 cells. BRD4 Inhibitor-15 can be used for prostate cancer research.

For research use only. We do not sell to patients.

BRD4 Inhibitor-15 Chemical Structure

BRD4 Inhibitor-15 Chemical Structure

CAS No. : 2761366-60-1

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BRD4 Inhibitor-15 Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

BRD4 Inhibitor-15 (compound 13) is a potent BRD4 inhibitor, with an IC50 of 18 nM. BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling pathway. BRD4 Inhibitor-15 down-regulates the c-Myc level in 22RV1 cells. BRD4 Inhibitor-15 can be used for prostate cancer research[1].

IC50 & Target

BRD4(1)

18 ± 1.1 nM (IC50)

Bcl-2

 

Bax

 

Caspase-3

 

Procaspase-3

 

In Vitro

BRD4 Inhibitor-15 (compound 13) shows potent anti-proliferative activity against enzalutamide-resistant 22RV1 cells and LNCap cells, with IC50 values of 8.27 ± 0.28 and 7.33 ± 0.49 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BRD4 Inhibitor-15 Related Antibodies
Molecular Weight

359.42

Formula

C22H21N3O2
CAS No.
SMILES

CCOC1=CC(N(C=C1C2=CC3=C(C=NN3CC4=CC=CC=C4)C=C2)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BRD4 Inhibitor-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD4 Inhibitor-152761366-60-1Epigenetic Reader DomainApoptosisBcl-2 FamilyCaspasec-MycMyc22RV1 cellsantitumorProstate cancerBRD4InhibitorResistancepyridone derivativesinhibitorinhibit

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