BRD9 Degrader-1 

BRD9 Degrader-1 (Compound 13-7) is a PROTAC BRD9 degrader^[1]. BRD9 Degrader-1 has a micromolar binding affinity for BRD9 and a nanomolar affinity for the BRD9-VCB ternary complex. BRD9 Degrader-1 induces BRD9 proteasome degradation in HEK293T cells, which can be reversed by MLN4924 (HY-70062)。(Blue: VH032-cyclopropane-F (HY-125905); Black: linker (HY-W763939); Pink: HY-168695)^[1].

1017.25

C₄₉H₆₅FN₁₂O₇S₂

[H][C@]1([C@@H](CCOC2=CC(C3=C(C)N=CS3)=CC=C2CNC([C@H]4N(C([C@H](C(C)(C)C)NC(C5(CC5)F)=O)=O)C[C@@H](C4)O)=O)[C@]1([H])C6)CN6C7=NC(N(C(C)C)CCNC(C)=O)=NC(N8CC(C8)OC9=NC=CS9)=N7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu S,et al. Rational Screening for Cooperativity in Small-Molecule Inducers of Protein-Protein Associations. J Am Chem Soc. 2023 Oct 25;145(42):23281-23291.  [Content Brief]