Bromo-PEG2-bromide

Name: Bromo-PEG2-bromide
Brand: MedChemExpress
SKU: HY-130589
Rating: 4.5 (1 reviews)

Cat. No.: HY-130589 Purity: 98.25%: FAQs
Data Sheet SDS COA Handling Instructions

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Bromo-PEG2-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Bromo-PEG2-bromide Chemical Structure

CAS No. : 31255-10-4

Size	Price	Stock	Quantity
50 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 95	In-stock	Estimated Time of Arrival: December 31
1 g	USD 220	Get quote	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Proteins:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Bromo-PEG2-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target^[1]

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

275.97

Formula

C₆H₁₂Br₂O₂

CAS No.

31255-10-4

Appearance

Liquid (Density: 1.6777 g/cm³)

Color

Colorless to light yellow

SMILES

BrCCOCCOCCBr

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (362.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6236 mL	18.1179 mL	36.2358 mL
5 mM	0.7247 mL	3.6236 mL	7.2472 mL
10 mM	0.3624 mL	1.8118 mL	3.6236 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.25%

Select Batch:

Data Sheet (266 KB) SDS (393 KB)

COA (240 KB) HNMR (115 KB) GC (209 KB)

Handling Instructions (2659 KB)

References

[1]. Chen TH, et al. Metal-organic frameworks constructed from crown ether-based 1,4-benzenedicarboxylic acid derivatives. Dalton Trans. 2016 Feb 21;45(7):3063-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6236 mL	18.1179 mL	36.2358 mL	90.5896 mL
	5 mM	0.7247 mL	3.6236 mL	7.2472 mL	18.1179 mL
	10 mM	0.3624 mL	1.8118 mL	3.6236 mL	9.0590 mL
	15 mM	0.2416 mL	1.2079 mL	2.4157 mL	6.0393 mL
	20 mM	0.1812 mL	0.9059 mL	1.8118 mL	4.5295 mL
	25 mM	0.1449 mL	0.7247 mL	1.4494 mL	3.6236 mL
	30 mM	0.1208 mL	0.6039 mL	1.2079 mL	3.0197 mL
	40 mM	0.0906 mL	0.4529 mL	0.9059 mL	2.2647 mL
	50 mM	0.0725 mL	0.3624 mL	0.7247 mL	1.8118 mL
	60 mM	0.0604 mL	0.3020 mL	0.6039 mL	1.5098 mL
	80 mM	0.0453 mL	0.2265 mL	0.4529 mL	1.1324 mL
	100 mM	0.0362 mL	0.1812 mL	0.3624 mL	0.9059 mL