2. PROTAC
  3. PROTAC Linkers
  4. Bromo-PEG3-CH2-Boc

Bromo-PEG3-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Bromo-PEG3-CH2-Boc Chemical Structure

Bromo-PEG3-CH2-Boc Chemical Structure

CAS No. : 2100306-71-4

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50 mg USD 95 In-stock
100 mg USD 150 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Bromo-PEG3-CH2-Boc Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Bromo-PEG3-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bromo-PEG3-CH2-Boc Related Antibodies
Molecular Weight

327.21

Formula

C12H23BrO5
CAS No.
Appearance

Liquid (Density: 1.246 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)COCCOCCOCCBr
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (305.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0561 mL 15.2807 mL 30.5614 mL
5 mM 0.6112 mL 3.0561 mL 6.1123 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (241 KB) HNMR (219 KB) MS (199 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0561 mL 15.2807 mL 30.5614 mL 76.4035 mL
5 mM 0.6112 mL 3.0561 mL 6.1123 mL 15.2807 mL
10 mM 0.3056 mL 1.5281 mL 3.0561 mL 7.6404 mL
15 mM 0.2037 mL 1.0187 mL 2.0374 mL 5.0936 mL
20 mM 0.1528 mL 0.7640 mL 1.5281 mL 3.8202 mL
25 mM 0.1222 mL 0.6112 mL 1.2225 mL 3.0561 mL
30 mM 0.1019 mL 0.5094 mL 1.0187 mL 2.5468 mL
40 mM 0.0764 mL 0.3820 mL 0.7640 mL 1.9101 mL
50 mM 0.0611 mL 0.3056 mL 0.6112 mL 1.5281 mL
60 mM 0.0509 mL 0.2547 mL 0.5094 mL 1.2734 mL
80 mM 0.0382 mL 0.1910 mL 0.3820 mL 0.9550 mL
100 mM 0.0306 mL 0.1528 mL 0.3056 mL 0.7640 mL
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Bromo-PEG3-CH2-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bromo-PEG3-CH2-Boc2100306-71-4PROTAC LinkersInhibitorinhibitorinhibit

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