2. Immunology/Inflammation
  3. NO Synthase
  4. Bryonolic acid

Bryonolic acid is an active triterpenoid compound with immunomodulatory, anti-inflammatory, antioxidant and anticancer activities.

For research use only. We do not sell to patients.

Bryonolic acid Chemical Structure

Bryonolic acid Chemical Structure

CAS No. : 24480-45-3

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Based on 1 publication(s) in Google Scholar

Bryonolic acid Related Antibodies

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Description

Bryonolic acid is an active triterpenoid compound with immunomodulatory, anti-inflammatory, antioxidant and anticancer activities[1][2][3].

Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
53.3 μM
Compound: 1, BA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
[PMID: 22339499]
In Vitro

Bryonolic acid exerts anti-allergic activity by inhibiting homologous passive cutaneous anaphylaxis and delayed hypersensitivity. Bryonolic acid reduces nitric oxide by suppressing inducible nitric oxide synthase expression, indicating anti-inflammatory activity[1].
In rat adrenal pheochromocytoma (PC12) cells, Bryonolic acid against N-methyl-D-aspartate (NMDA)-induced neurotoxicity, indicating it as a candidate neuroprotective agent for cerebral ischemic treatment[1].
Bryonolic acid (1-200 μM) inhibits acyl-coA: cholesterol acyl transferase (ACAT) activity in rat liver microsomes in a concentration-dependent manner, blocking the biosynthesis of the cholesterol fatty acid ester tumour promoter. Bryonolic acid inhibits ACAT in intact cancer cells with an IC50 of 12.6 µM[2].
Bryonolic acid inhibits both clonogenicity and invasiveness in MCF-7 MB-231, U87 and 3T3-EA cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bryonolic acid Related Antibodies
In Vivo

Bryonolic acid (500 mg/kg; i.p.; once) potently induces HO-1 in a manner dependent on the Nrf2-Keap1 pathway[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type and Nrf2-/- mice[3]
Dosage: 500 mg/kg
Administration: i.p.; once
Result: Induced HO-1 in a manner dependent on the Nrf2-Keap1 pathway.
Molecular Weight

456.70

Formula

C30H48O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@@](C)(C3)C(O)=O)C)(CCC4=C2CC[C@]5([H])[C@@]4(CC[C@@H](C5(C)C)O)C)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Bryonolic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bryonolic acid24480-45-3NO SynthaseNitric oxide synthasesNOSimmunomodulatoryanti-inflammatorycytoprotectivecytotoxicityanti-allergicanticancerInhibitorinhibitorinhibit

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