2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. BS3 Crosslinker

BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

BS3 Crosslinker Chemical Structure

BS3 Crosslinker Chemical Structure

CAS No. : 82436-77-9

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of BS3 Crosslinker:

BS3 Crosslinker Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Non-cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BS3 Crosslinker Related Antibodies
Molecular Weight

528.47

Formula

C16H20N2O14S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCCCCCC(ON1C(C(CC1=O)S(=O)(O)=O)=O)=O)ON2C(C(CC2=O)S(=O)(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (331.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (189.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8923 mL 9.4613 mL 18.9226 mL
5 mM 0.3785 mL 1.8923 mL 3.7845 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (246 KB) HNMR (272 KB) MS (74 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.8923 mL 9.4613 mL 18.9226 mL 47.3064 mL
5 mM 0.3785 mL 1.8923 mL 3.7845 mL 9.4613 mL
10 mM 0.1892 mL 0.9461 mL 1.8923 mL 4.7306 mL
15 mM 0.1262 mL 0.6308 mL 1.2615 mL 3.1538 mL
20 mM 0.0946 mL 0.4731 mL 0.9461 mL 2.3653 mL
25 mM 0.0757 mL 0.3785 mL 0.7569 mL 1.8923 mL
30 mM 0.0631 mL 0.3154 mL 0.6308 mL 1.5769 mL
40 mM 0.0473 mL 0.2365 mL 0.4731 mL 1.1827 mL
50 mM 0.0378 mL 0.1892 mL 0.3785 mL 0.9461 mL
60 mM 0.0315 mL 0.1577 mL 0.3154 mL 0.7884 mL
80 mM 0.0237 mL 0.1183 mL 0.2365 mL 0.5913 mL
100 mM 0.0189 mL 0.0946 mL 0.1892 mL 0.4731 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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BS3 Crosslinker Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BS3 Crosslinker82436-77-9ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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BS3 Crosslinker
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