2. Neuronal Signaling
  3. Amyloid-β
  4. BSB

BSB  (Synonyms: (trans,trans)-1-Bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene)

Cat. No.: HY-D1443 Purity: 97.24%
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BSB is a Congo red-derived fluorescent probe. BSB binds not only to extracellular amyloid β protein, but also many intracellular lesions composed of abnormal tau and synuclein proteins. BSB acts as a prototype imaging agent for Alzheimer's disease.

For research use only. We do not sell to patients.

BSB Chemical Structure

BSB Chemical Structure

CAS No. : 291766-06-8

Size Price Stock Quantity
5 mg USD 175 In-stock
10 mg USD 280 In-stock
25 mg USD 530 In-stock
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Based on 1 publication(s) in Google Scholar

BSB Related Antibodies

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Description

BSB is a Congo red-derived fluorescent probe. BSB binds not only to extracellular amyloid β protein, but also many intracellular lesions composed of abnormal tau and synuclein proteins. BSB acts as a prototype imaging agent for Alzheimer's disease[1].

Molecular Weight

481.29

Formula

C24H17BrO6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

BrC1=CC(/C=C/C2=CC=C(O)C(C(O)=O)=C2)=CC=C1/C=C/C3=CC=C(O)C(C(O)=O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (207.77 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0777 mL 10.3887 mL 20.7775 mL
5 mM 0.4155 mL 2.0777 mL 4.1555 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0777 mL 10.3887 mL 20.7775 mL 51.9437 mL
5 mM 0.4155 mL 2.0777 mL 4.1555 mL 10.3887 mL
10 mM 0.2078 mL 1.0389 mL 2.0777 mL 5.1944 mL
15 mM 0.1385 mL 0.6926 mL 1.3852 mL 3.4629 mL
20 mM 0.1039 mL 0.5194 mL 1.0389 mL 2.5972 mL
25 mM 0.0831 mL 0.4155 mL 0.8311 mL 2.0777 mL
30 mM 0.0693 mL 0.3463 mL 0.6926 mL 1.7315 mL
40 mM 0.0519 mL 0.2597 mL 0.5194 mL 1.2986 mL
50 mM 0.0416 mL 0.2078 mL 0.4155 mL 1.0389 mL
60 mM 0.0346 mL 0.1731 mL 0.3463 mL 0.8657 mL
80 mM 0.0260 mL 0.1299 mL 0.2597 mL 0.6493 mL
100 mM 0.0208 mL 0.1039 mL 0.2078 mL 0.5194 mL
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BSB Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BSB291766-06-8(trans,trans)-1-Bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzeneAmyloid-ββ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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