2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. BTT-266

BTT-266 is an antagonist forcalcium channel, through suppression of the CaVα1-AID-CaVβ3 interaction, with a Ki of 1.4 μM. BTT-266 modulates the activation of voltage-dependent CaV2.2. BTT-266 exhibits analgesic efficacy against neuropathic pain in rats model.

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BTT-266 Chemical Structure

BTT-266 Chemical Structure

CAS No. : 2413939-89-4

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BTT-266 Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

BTT-266 is an antagonist forcalcium channel, through suppression of the CaVα1-AID-CaVβ3 interaction, with a Ki of 1.4 μM. BTT-266 modulates the activation of voltage-dependent CaV2.2. BTT-266 exhibits analgesic efficacy against neuropathic pain in rats model[1].

Molecular Weight

556.61

Formula

C34H28N4O4
CAS No.
SMILES

O=C(C1=CC=CC(C(N2N=C(CC2C3=CN(C4=CC=CC=C4)N=C3C5=CC=C(C)C=C5)C6=CC=C(OC)C=C6)=O)=C1)O
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BTT-266 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTT-2662413939-89-4BTT266BTT 266Calcium ChannelCa2+ channelsCa channelsHEK-CaV2.2 cellsSprague-Dawley ratsanalgesicInhibitorinhibitorinhibit

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