BuChE-IN-7 

BuChE-IN-7 is a highly selective inhibitor of hBuChe and eqBuChE with IC₅₀ values of 40 nM, 80 nM respectively. BuChE-IN-7 can promote cognitive with blood-brain penetration and improves situational and phobic memory, showing preference for new things^[1].

BuChE-IN-7 (compound (R)-29) (10 µM; 5 min) inhibits eqBuChE, hBuChE with IC₅₀ values of 0.08 µM, 0.04 µM respectively^[1].
BuChE-IN-7 (1, 10, 50 and 100 µM; 72 h) has hepatotoxicity in HepG2 cell line with an IC₅₀ value of 2.85 µM. BuChE-IN-7 decreas the cell activity and shows weaker effect on CYP3A4^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BuChE-IN-7 (compound (R)-29) (10 mg/kg and 30 mg/kg; i.p.; single dose) has no effect on memory improvement function of amnesia mouse model caused by Scopolamine (HY-N0296), and also has blood-brain penetration^[1].
BuChE-IN-7 (10 mg/kg; i.p.; once daily for 6 days) has insignificant improvement the learning defect caused by scopolamine in mice^[1].
BuChE-IN-7 (15 mg/kg and 30 mg/kg; i.p.; single dose) significantly promotes cognition and improves situational and phobic memory of mice, showing preference for new things^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

394.55

C₂₅H₃₄N₂O₂

O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)NC[C@H](O)CNCC3CCCCC3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Panek D, et al. Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies. Eur J Med Chem. 2023 Jan 18;249:115135.  [Content Brief]