2. Anti-infection
  3. Parasite
  4. Bulaquine

Bulaquine  (Synonyms: CDRI 80/53; Elubaquine)

Cat. No.: HY-106866
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Bulaquine (CDRI 80/53) is a potent antimalarial agent which is an analogue of Primaquine (HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect on Plasmodium cynomolgi infection. Bulaquine can be used for the research of malaria.

For research use only. We do not sell to patients.

Bulaquine Chemical Structure

Bulaquine Chemical Structure

CAS No. : 79781-00-3

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Bulaquine Related Antibodies

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Description

Bulaquine (CDRI 80/53) is a potent antimalarial agent which is an analogue of Primaquine (HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect on Plasmodium cynomolgi infection. Bulaquine can be used for the research of malaria[1][2][3].

IC50 & Target

Plasmodium

 

Cellular Effect
Cell Line Type Value Description References
Huh-7 IC50
10 μM
Compound: 2
Antiplasmodial activity against liver stage Plasmodium berghei infected in Huh7 cells assessed as inhibition of parasite infection incubated for 1 hr prior to infection measured at 24 hrs by luciferase reporter gene assay
Antiplasmodial activity against liver stage Plasmodium berghei infected in Huh7 cells assessed as inhibition of parasite infection incubated for 1 hr prior to infection measured at 24 hrs by luciferase reporter gene assay
[PMID: 26968650]
In Vivo

Bulaquine (40 mg/kg; p.o. once) affects multiple pathways in vivo[1].
Bulaquine (1.25 mg/kg; once daily; for 7 days) shows 100% curative anti-relapse activity with a primaquine index of 0.8 for rhesus monkeys with Plasmodium cynomolgi B infection[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 25-30 g male Swiss albino mice[1]
Dosage: 40 mg/kg
Administration: Oral gavage; 40 mg/kg once
Result: Affected oxidative stress and fatty acid synthesis pathway, apoptosis, cell cycle, inflammatory response, glycogen metabolism, Kreb’s cycle, electron transport chain, fatty acid β-oxidation, MAPK signalling, signalling of hepatocyte growth factor receptor, matrix metalloproteinases, steroid biosynthesis, TGF-β signalling, translation factors, Wnt signalling, regulation of actin cytoskeleton, ribosomal proteins, RNA transcription reactome, proteasome degradation and nuclear receptors in lipid metabolism according to GO results.
Molecular Weight

369.46

Formula

C21H27N3O3
CAS No.
SMILES

C/C(NCCCC(NC1=CC(OC)=CC2=C1N=CC=C2)C)=C3C(OCC/3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Bulaquine Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bulaquine79781-00-3CDRI 80/53 ElubaquineParasitemalariainfectionprimaquinePlasmodium cynomolgimiceInhibitorinhibitorinhibit

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