Bunitrolol  (Synonyms: KO 1366)

Bunitrolol hydrochloride is an orally active β-adrenergic blocker that has a high affinity for β-adrenergic receptors. Bunitrolol hydrochloride exerts significant β-receptor antagonist activity and has weak α₁-blocking activity. Bunitrolol hydrochloride is mainly used in the study of cardiovascular diseases such as hypertension and angina pectoris, and is also used in placental transport research^[1][2][3].

248.32

C₁₄H₂₀N₂O₂

34915-68-9

Oil

Colorless to light yellow

N#CC1=CC=CC=C1OCC(CNC(C)(C)C)O

Room temperature in continental US; may vary elsewhere.

• [1]. Tsuchihashi H, et al. Effects of bunitrolol on adrenergic and serotonergic receptors. Jpn J Pharmacol. 1987 Nov;45(3):349-56.  [Content Brief]

  [2]. Hasegawa Y, et al. Chronic effects of bunitrolol and pindolol on blood pressure, heart rate, vascular lesions, and plasma renin activity in hypertensive rats. Jpn J Pharmacol. 1982 Aug;32(4):742-5.  [Content Brief]

  [3]. Van Petten G R, et al. Chronic preparation of the pregnant ewe and fetus for pharmacological research: the placental transfer and fetal effects of bunitrolol. Journal of Pharmacological Methods, 1978, 1(1): 45-60.