Bupivacaine-d₉

Cat. No.: HY-B0405S Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Bupivacaine-d₉9 is a deuterium labeled Bupivacaine. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain[1][2][3].

For research use only. We do not sell to patients.

Bupivacaine-d<sub>9</sub> Chemical Structure

Bupivacaine-d₉ Chemical Structure

CAS No. : 474668-57-0

Size	Price	Stock	Quantity
1 mg		In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

Other Forms of Bupivacaine-d₉:

Bupivacaine Get quote
Bupivacaine hydrochloride monohydrate Get quote

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AMPA Receptor NMDA Receptor Kainate Receptor

View All Sodium Channel Isoform Specific Products:

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Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8

View All Calcium Channel Isoform Specific Products:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

NMDA Receptor

Molecular Weight

297.48

Formula

C₁₈H₁₉D₉N₂O

CAS No.

474668-57-0

Unlabeled CAS

38396-39-3

Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=CC(C)=C1NC(C2N(CCCC2)C([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (336.16 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3616 mL	16.8079 mL	33.6157 mL
5 mM	0.6723 mL	3.3616 mL	6.7231 mL
10 mM	0.3362 mL	1.6808 mL	3.3616 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (281 KB) SDS (480 KB)

COA (261 KB)

Handling Instructions (2659 KB)

References

[1]. Stoetzer C, et al. Inhibition of Voltage-Gated Na+ Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine. Reg Anesth Pain Med. 2017;42(4):462-468. [Content Brief]

[2]. Schwoerer AP, et al. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels. Anesth Analg. 2015;120(6):1226-1234. [Content Brief]

[3]. Paganelli MA, et al. Actions of bupivacaine, a widely used local anesthetic, on NMDA receptor responses. J Neurosci. 2015;35(2):831-842. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3616 mL	16.8079 mL	33.6157 mL	84.0393 mL
	5 mM	0.6723 mL	3.3616 mL	6.7231 mL	16.8079 mL
	10 mM	0.3362 mL	1.6808 mL	3.3616 mL	8.4039 mL
	15 mM	0.2241 mL	1.1205 mL	2.2410 mL	5.6026 mL
	20 mM	0.1681 mL	0.8404 mL	1.6808 mL	4.2020 mL
	25 mM	0.1345 mL	0.6723 mL	1.3446 mL	3.3616 mL
	30 mM	0.1121 mL	0.5603 mL	1.1205 mL	2.8013 mL
	40 mM	0.0840 mL	0.4202 mL	0.8404 mL	2.1010 mL
	50 mM	0.0672 mL	0.3362 mL	0.6723 mL	1.6808 mL
	60 mM	0.0560 mL	0.2801 mL	0.5603 mL	1.4007 mL
	80 mM	0.0420 mL	0.2101 mL	0.4202 mL	1.0505 mL
	100 mM	0.0336 mL	0.1681 mL	0.3362 mL	0.8404 mL