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Butabindide oxalate  (Synonyms: UCL-1397 oxalate)

Cat. No.: HY-107759 Purity: 98.98%
SDS COA Handling Instructions

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Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation.

For research use only. We do not sell to patients.

Butabindide oxalate Chemical Structure

Butabindide oxalate Chemical Structure

CAS No. : 185213-03-0

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1 mg USD 70 In-stock
5 mg USD 180 In-stock
10 mg USD 300 In-stock
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Based on 1 publication(s) in Google Scholar

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Butabindide oxalate Related Antibodies

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Description

Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation[1][2].

IC50 & Target

IC50: 7 nM (TPP II) and 10 μM (TPP I)[1]
In Vitro

Butabindide (UCL-1397; 0-24 nM; membranes of rat cerebral cortex) oxalate inhibits TPP II activity of cerebral membranes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Butabindide oxalate Related Antibodies
In Vivo

Butabindide (UCL-1397; 10 mg/kg; i.v.; for 20 min) oxalate inhibits the breakdown of CCK-8 in the gastrointestinal tract and increases satiety in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (25-30 g)[2]
Dosage: 10 mg/kg
Administration: Intravenous injection; for 20 minutes
Result: Reduces food intake and elicits other behavioral concomitants of satiation.
Molecular Weight

393.43

Formula

C19H27N3O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1N(C([C@@H](N)CC)=O)C2=C(C=CC=C2)C1)NCCCC.O=C(O)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 39 mg/mL (99.13 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5417 mL 12.7087 mL 25.4175 mL
5 mM 0.5083 mL 2.5417 mL 5.0835 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.98%

SDS (393 KB)

COA (253 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.5417 mL 12.7087 mL 25.4175 mL 63.5437 mL
5 mM 0.5083 mL 2.5417 mL 5.0835 mL 12.7087 mL
10 mM 0.2542 mL 1.2709 mL 2.5417 mL 6.3544 mL
15 mM 0.1694 mL 0.8472 mL 1.6945 mL 4.2362 mL
20 mM 0.1271 mL 0.6354 mL 1.2709 mL 3.1772 mL
25 mM 0.1017 mL 0.5083 mL 1.0167 mL 2.5417 mL
30 mM 0.0847 mL 0.4236 mL 0.8472 mL 2.1181 mL
40 mM 0.0635 mL 0.3177 mL 0.6354 mL 1.5886 mL
50 mM 0.0508 mL 0.2542 mL 0.5083 mL 1.2709 mL
60 mM 0.0424 mL 0.2118 mL 0.4236 mL 1.0591 mL
80 mM 0.0318 mL 0.1589 mL 0.3177 mL 0.7943 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Butabindide oxalate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Butabindide185213-03-0UCL-1397UCL1397UCL 1397Otherscholecystokinintripeptidylpeptidaselysosomeneuronal ceroid lipofuscinosisInhibitorinhibitorinhibit

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