BVT.13

Cat. No.: HY-114853: FAQs
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BVT.13 is an orally active and selective PPARγ agonist with a maximal efficacy similar to that of Rosiglitazone (HY-17386). In addition, BVT.13 exhibits antidiabetic activity in ob/ob mice.

For research use only. We do not sell to patients.

BVT.13 Chemical Structure

CAS No. : 756813-87-3

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PPARα PPARβ/δ PPARγ PPAR PPARδ

Biological Activity
Purity & Documentation
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Description

BVT.13 is an orally active and selective PPARγ agonist with a maximal efficacy similar to that of Rosiglitazone (HY-17386). In addition, BVT.13 exhibits antidiabetic activity in ob/ob mice^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	1.3 μM Compound: 6, BVT.13	Activity at human PPARgamma transfected in HEK293 cells assessed as transactivation activity by luciferase reporter gene assay Activity at human PPARgamma transfected in HEK293 cells assessed as transactivation activity by luciferase reporter gene assay	[PMID: 25734377]

Molecular Weight

404.20

Formula

C₁₈H₁₁Cl₂N₃O₄

CAS No.

756813-87-3

SMILES

O=C(O)C1=CC(OC2=NC=CC=N2)=CC=C1NC(C3=CC=C(Cl)C=C3Cl)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ostberg T, et al. A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects[J]. Journal of Biological Chemistry, 2004, 279(39): 41124-41130. [Content Brief]

BVT.13 Related Classifications

Metabolic Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BVT.13756813-87-3PPARPeroxisome proliferator-activated receptorsOrally activeagonistantidiabeticob/ob miceInhibitorinhibitorinhibit

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