BVT-2733 hydrochloride

Cat. No.: HY-18054A: Data Sheet Handling Instructions Technical Support

BVT-2733 hydrochloride is a potent, selective and orally active nonsteroidal 11β-HSD1 inhibitor. BVT-2733 hydrochloride is more potent against mouse 11β-HSD1 enzyme (IC₅₀=96 nM) than against human 11β-HSD1 enzyme (IC₅₀=3341 nM). BVT-2733 hydrochloride has the potential to be used in the study of arthritis and obesity-related diseases.

For research use only. We do not sell to patients.

BVT-2733 hydrochloride Chemical Structure

CAS No. : 376641-65-5

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of BVT-2733 hydrochloride:

BVT 2733

Other Forms of BVT-2733 hydrochloride:

BVT 2733 In-stock

4 Publications Citing Use of MCE BVT-2733 hydrochloride

Biological Activity
Purity & Documentation
References
Customer Review

Description	BVT-2733 hydrochloride is a potent, selective and orally active nonsteroidal 11β-HSD1 inhibitor. BVT-2733 hydrochloride is more potent against mouse 11β-HSD1 enzyme (IC₅₀=96 nM) than against human 11β-HSD1 enzyme (IC₅₀=3341 nM). BVT-2733 hydrochloride has the potential to be used in the study of arthritis and obesity-related diseases^[1]^[2]^[3].
Molecular Weight	465.42
Formula	C₁₇H₂₂Cl₂N₄O₃S₂
CAS No.	376641-65-5
SMILES	O=S(C1=CC=CC(Cl)=C1C)(NC2=NC(CC(N3CCN(C)CC3)=O)=CS2)=O.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. 11β-hydroxydehydrogenase 1 (11β-HSD1) Inhibitor in Development [2]. Zhang L, et al. 11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis. Int Immunopharmacol. 2013 Nov;17(3):489-94. [Content Brief] [3]. Wang L, et al. BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice. PLoS One. 2012;7(7):e40056. [Content Brief]