2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Bz-(Me)Tz-NHS

Bz-(Me)Tz-NHS is a click chemistry reagent containing an methyltetrazine group. Bz-(Me)Tz-NHS is 3rd generation Click-Linker for Cu-free click conjugation.

For research use only. We do not sell to patients.

Bz-(Me)Tz-NHS Chemical Structure

Bz-(Me)Tz-NHS Chemical Structure

CAS No. : 1454558-58-7

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10 mg USD 110 In-stock
25 mg USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

Bz-(Me)Tz-NHS Related Antibodies

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Description

Bz-(Me)Tz-NHS is a click chemistry reagent containing an methyltetrazine group. Bz-(Me)Tz-NHS is 3rd generation Click-Linker for Cu-free click conjugation[1].

Molecular Weight

412.40

Formula

C19H20N6O5
CAS No.
Appearance

Solid

Color

Purple to purplish red

SMILES

O=C(CCCC(NCC1=CC=C(C2=NN=C(C)N=N2)C=C1)=O)ON3C(CCC3=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (60.62 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4248 mL 12.1242 mL 24.2483 mL
5 mM 0.4850 mL 2.4248 mL 4.8497 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4248 mL 12.1242 mL 24.2483 mL 60.6208 mL
5 mM 0.4850 mL 2.4248 mL 4.8497 mL 12.1242 mL
10 mM 0.2425 mL 1.2124 mL 2.4248 mL 6.0621 mL
15 mM 0.1617 mL 0.8083 mL 1.6166 mL 4.0414 mL
20 mM 0.1212 mL 0.6062 mL 1.2124 mL 3.0310 mL
25 mM 0.0970 mL 0.4850 mL 0.9699 mL 2.4248 mL
30 mM 0.0808 mL 0.4041 mL 0.8083 mL 2.0207 mL
40 mM 0.0606 mL 0.3031 mL 0.6062 mL 1.5155 mL
50 mM 0.0485 mL 0.2425 mL 0.4850 mL 1.2124 mL
60 mM 0.0404 mL 0.2021 mL 0.4041 mL 1.0103 mL
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Bz-(Me)Tz-NHS Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bz-(Me)Tz-NHS1454558-58-7ADC LinkerAntibody-drug conjugates linkerclick chemistryreagentmethyltetrazinebiochemicalInhibitorinhibitorinhibit

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