2. Immunology/Inflammation
  3. Complement System
  4. C1s-IN-1 trihydrochloride

C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the Ki of 5.8 μM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC50 of 85 μM, inhibits the activation of classic pathway with an IC50 of 22 μM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the Ki of 51.2 μM.

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C1s-IN-1 trihydrochloride Chemical Structure

C1s-IN-1 trihydrochloride Chemical Structure

CAS No. : 1376162-36-5

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C1s-IN-1 trihydrochloride Related Antibodies

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Description

C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the Ki of 5.8 μM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC50 of 85 μM, inhibits the activation of classic pathway with an IC50 of 22 μM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the Ki of 51.2 μM[1].

IC50 & Target

Ki: 5.8 μM (C1s protease); 51.2 μM (thrombin)
Molecular Weight

390.74

Formula

C16H22Cl3N5
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

N=C(C1=CN=C(N2CCN(CC2)C3=CC=CC=C3)C=C1)N.Cl.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (319.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5592 mL 12.7962 mL 25.5925 mL
5 mM 0.5118 mL 2.5592 mL 5.1185 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5592 mL 12.7962 mL 25.5925 mL 63.9812 mL
5 mM 0.5118 mL 2.5592 mL 5.1185 mL 12.7962 mL
10 mM 0.2559 mL 1.2796 mL 2.5592 mL 6.3981 mL
15 mM 0.1706 mL 0.8531 mL 1.7062 mL 4.2654 mL
20 mM 0.1280 mL 0.6398 mL 1.2796 mL 3.1991 mL
25 mM 0.1024 mL 0.5118 mL 1.0237 mL 2.5592 mL
30 mM 0.0853 mL 0.4265 mL 0.8531 mL 2.1327 mL
40 mM 0.0640 mL 0.3199 mL 0.6398 mL 1.5995 mL
50 mM 0.0512 mL 0.2559 mL 0.5118 mL 1.2796 mL
60 mM 0.0427 mL 0.2133 mL 0.4265 mL 1.0664 mL
80 mM 0.0320 mL 0.1600 mL 0.3199 mL 0.7998 mL
100 mM 0.0256 mL 0.1280 mL 0.2559 mL 0.6398 mL
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C1s-IN-1 trihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C1s-IN-1 trihydrochloride1376162-36-5Complement SystemselectivecompetitiveInhibitorinhibitorinhibit

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