2. Anti-infection
  3. Bacterial
  4. Ca(II)-EDTA disodium dihydrate

Ca(II)-EDTA disodium dihydrate  (Synonyms: Calcium disodium EDTA dihydrate)

Cat. No.: HY-W749867 Purity: ≥95.0%
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CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis. CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning.

For research use only. We do not sell to patients.

Ca(II)-EDTA disodium dihydrate Chemical Structure

Ca(II)-EDTA disodium dihydrate Chemical Structure

CAS No. : 6766-87-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Ca(II)-EDTA disodium dihydrate:

Ca(II)-EDTA disodium dihydrate Related Antibodies

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Description

CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis[1]. CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning[2][3].

In Vitro

CaⅡ-EDTA disodium dehydrate (0-100 mM) inhibits growths of periodontopathic bacteria A. actinomycetemcomitans, P. intermedia and P. gingivalis, with MICs of 70, 70 and 60 mM, respectively[1].
CaⅡ-EDTA disodium dehydrate (0-1000 mM) exhibits cytotoxicity in L929 cells and a safe dose of 75 mM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ca(II)-EDTA disodium dihydrate Related Antibodies

Cell Viability Assay[1]

Cell Line: Murine L929 cells
Concentration: 0-1000 mM
Incubation Time: 24 h
Result: Reduced cell viability in a dose-dependent manner. Remained a survival rate of 93% at the concentration of 75 mM.
In Vivo

CaⅡ-EDTA disodium dehydrate (50 mg/kg, p.o. for 4 weeks) alleviates the toxic effects of cadmium on kidney and bone with preference to the nanoparticles form[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley rats [2]
Dosage: 50 mg/kg/day
Administration: p.o. for 4 weeks (three-day break after each four consecutive days of administration)
Result: Increased the body weight compared to the Cd-intoxicated group.
Decreased in serum creatinine and cadmium concentration compared to the Cd-intoxicated group.
Showed a good radio-density of the skeleton.
Molecular Weight

410.30

Formula

C10H12CaN2O8.2H2.2Na
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1[O-][Ca+2]([N]2(C1)CC3=O)([O-]3)([O-]C4=O)([O-]5)[N](C4)(CC2)CC5=O.[2].[2].[Na+].O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (243.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4372 mL 12.1862 mL 24.3724 mL
5 mM 0.4874 mL 2.4372 mL 4.8745 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥95.0%

SDS (393 KB)

COA (263 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.4372 mL 12.1862 mL 24.3724 mL 60.9310 mL
5 mM 0.4874 mL 2.4372 mL 4.8745 mL 12.1862 mL
10 mM 0.2437 mL 1.2186 mL 2.4372 mL 6.0931 mL
15 mM 0.1625 mL 0.8124 mL 1.6248 mL 4.0621 mL
20 mM 0.1219 mL 0.6093 mL 1.2186 mL 3.0466 mL
25 mM 0.0975 mL 0.4874 mL 0.9749 mL 2.4372 mL
30 mM 0.0812 mL 0.4062 mL 0.8124 mL 2.0310 mL
40 mM 0.0609 mL 0.3047 mL 0.6093 mL 1.5233 mL
50 mM 0.0487 mL 0.2437 mL 0.4874 mL 1.2186 mL
60 mM 0.0406 mL 0.2031 mL 0.4062 mL 1.0155 mL
80 mM 0.0305 mL 0.1523 mL 0.3047 mL 0.7616 mL
100 mM 0.0244 mL 0.1219 mL 0.2437 mL 0.6093 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ca(II)-EDTA disodium dihydrate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ca(II)-EDTA disodium dihydrate6766-87-6Calcium disodium EDTA dihydrateBacterialAggregatibacter actinomycetemcomitansPrevotella intermediaPorphyromonas gingivalisperiodontal diseasemurine L929Inhibitorinhibitorinhibit

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