Calindol hydrochloride

Name: Calindol hydrochloride
Brand: MedChemExpress
SKU: HY-122819
Rating: 4.5 (1 reviews)

Cat. No.: HY-122819 Purity: 99.88%: FAQs
Data Sheet SDS COA Handling Instructions

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Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC₅₀ of 132 nM.

For research use only. We do not sell to patients.

Calindol hydrochloride Chemical Structure

CAS No. : 729610-18-8

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5 mg	USD 185	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 315	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 660	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1050	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1680	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC₅₀ of 132 nM^[1].

In Vitro

In the presence of 2mM Ca²⁺, Calindol stimulates phosphatidylinositol (PI) accumulation with an EC₅₀ of 1.0 μM or 0.31 μM in cells expressing the rat or the human CaSR, respectively^[2].
In wire myography studies, Calindol (1-10 μM) inhibits Methoxamine- and KCl-induced pre-contracted tone, and inhibits whole-cell voltage-gated Ca²⁺ channel (VGCC) currents in rabbit mesenteric arteries^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

336.86

Formula

C₂₁H₂₁ClN₂

CAS No.

729610-18-8

Appearance

Solid

Color

White to light yellow

SMILES

C[C@@H](NCC1=CC2=CC=CC=C2N1)C3=C4C=CC=CC4=CC=C3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (296.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9686 mL	14.8430 mL	29.6859 mL
5 mM	0.5937 mL	2.9686 mL	5.9372 mL
10 mM	0.2969 mL	1.4843 mL	2.9686 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (276 KB) SDS (392 KB)

COA (254 KB) HNMR (121 KB) RP-HPLC (226 KB) LCMS (224 KB)

Handling Instructions (2659 KB)

References

[1]. Lionel Kiefer, et al. Design and synthesis of calindol derivatives as potent and selective calcium sensing receptor agonists. Bioorg Med Chem. 2016 Feb 15;24(4):554-69. [Content Brief]

[2]. Albane Kessler, et al. N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3345-9. [Content Brief]

[3]. Harry Z E Greenberg, et al. The calcilytics Calhex-231 and NPS 2143 and the calcimimetic Calindol reduce vascular reactivity via inhibition of voltage-gated Ca2+ channels. Eur J Pharmacol. 2016 Nov 15;791:659-668. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9686 mL	14.8430 mL	29.6859 mL	74.2148 mL
	5 mM	0.5937 mL	2.9686 mL	5.9372 mL	14.8430 mL
	10 mM	0.2969 mL	1.4843 mL	2.9686 mL	7.4215 mL
	15 mM	0.1979 mL	0.9895 mL	1.9791 mL	4.9477 mL
	20 mM	0.1484 mL	0.7421 mL	1.4843 mL	3.7107 mL
	25 mM	0.1187 mL	0.5937 mL	1.1874 mL	2.9686 mL
	30 mM	0.0990 mL	0.4948 mL	0.9895 mL	2.4738 mL
	40 mM	0.0742 mL	0.3711 mL	0.7421 mL	1.8554 mL
	50 mM	0.0594 mL	0.2969 mL	0.5937 mL	1.4843 mL
	60 mM	0.0495 mL	0.2474 mL	0.4948 mL	1.2369 mL
	80 mM	0.0371 mL	0.1855 mL	0.3711 mL	0.9277 mL
	100 mM	0.0297 mL	0.1484 mL	0.2969 mL	0.7421 mL