2. Immunology/Inflammation
  3. Interleukin Related
  4. Canakinumab

Canakinumab  (Synonyms: Ilaris; ACZ 885)

Cat. No.: HY-108810 Purity: 99.64%
COA

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Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin.

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CAS No. : 914613-48-2

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Based on 1 publication(s) in Google Scholar

Canakinumab Related Antibodies

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Description

Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin[1][2].

Isotype

Human IgG1(K214R) kappa
Recommend Isotype Controls
Species

Human
IC50 & Target

IC50: 43.6 pM (human IL-1β), 40.8 pM (marmoset IL-1β)[2]
In Vitro

Canakinumab (0-7 nM) dose dependently represses IL-6 production in marmoset peripheral blood mononuclear cells with IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β[2]. Canakinumab effectively competes with IL-1RI and IL-1RII for binding to IL-1b[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Canakinumab Related Antibodies
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Canakinumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation

Purity: 99.64%

COA (231 KB) SDS-PAGE (116 KB) SEC-HPLC (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Canakinumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Canakinumab914613-48-2Ilaris ACZ 885ACZ885ACZ 885ACZ-885Interleukin RelatedILrecombinanthumanmonoclonalantibodyautoimmuneIL-6IL-1RIIL-1RIIInhibitorinhibitorinhibit

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