1. Immunology/Inflammation
  2. Interleukin Related
  3. Canakinumab

Canakinumab  (Synonyms: Ilaris; ACZ 885)

Cat. No.: HY-108810 Purity: 99.64%
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Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin.

For research use only. We do not sell to patients.

CAS No. : 914613-48-2

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Based on 1 publication(s) in Google Scholar

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Description

Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin[1][2].

Isotype

Human IgG1(K214R) kappa

Recommend Isotype Controls
Species

Human

IC50 & Target

IC50: 43.6 pM (human IL-1β), 40.8 pM (marmoset IL-1β)[2]

In Vitro

Canakinumab (0-7 nM) dose dependently represses IL-6 production in marmoset peripheral blood mononuclear cells with IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β[2]. Canakinumab effectively competes with IL-1RI and IL-1RII for binding to IL-1b[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

145500.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Canakinumab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized IL-1 beta Protein, Human (HY-P7028) can bind Canakinumab. The EC50 for this effect is 6.151 ng/mL.
Purity & Documentation

Purity: 99.64%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Canakinumab
Cat. No.:
HY-108810
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