Candesartan methyl ester

Cat. No.: HY-W098792: FAQs
Data Sheet Handling Instructions Technical Support

Candesartan methyl ester is an antagonist for angiotensin II (AII) receptor with an IC₅₀ of 0.11 μM. Candesartan methyl ester exhibits blood pressure lowering activity in rats models.

For research use only. We do not sell to patients.

Candesartan methyl ester Chemical Structure

CAS No. : 139481-69-9

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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AT1 Receptor AT2 Receptor

Biological Activity
Purity & Documentation
References
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Description

Candesartan methyl ester is an antagonist for angiotensin II (AII) receptor with an IC₅₀ of 0.11 μM. Candesartan methyl ester exhibits blood pressure lowering activity in rats models^[1].

IC₅₀ & Target

AT2 Receptor

0.11 μM (IC₅₀)

Molecular Weight

454.48

Formula

C₂₅H₂₂N₆O₃

CAS No.

139481-69-9

SMILES

CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (220.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2003 mL	11.0016 mL	22.0032 mL
5 mM	0.4401 mL	2.2003 mL	4.4006 mL
10 mM	0.2200 mL	1.1002 mL	2.2003 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kohara Y, et al., Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole bioisosteres. J Med Chem. 1996 Dec 20;39(26):5228-35. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2003 mL	11.0016 mL	22.0032 mL	55.0079 mL
	5 mM	0.4401 mL	2.2003 mL	4.4006 mL	11.0016 mL
	10 mM	0.2200 mL	1.1002 mL	2.2003 mL	5.5008 mL
	15 mM	0.1467 mL	0.7334 mL	1.4669 mL	3.6672 mL
	20 mM	0.1100 mL	0.5501 mL	1.1002 mL	2.7504 mL
	25 mM	0.0880 mL	0.4401 mL	0.8801 mL	2.2003 mL
	30 mM	0.0733 mL	0.3667 mL	0.7334 mL	1.8336 mL
	40 mM	0.0550 mL	0.2750 mL	0.5501 mL	1.3752 mL
	50 mM	0.0440 mL	0.2200 mL	0.4401 mL	1.1002 mL
	60 mM	0.0367 mL	0.1834 mL	0.3667 mL	0.9168 mL
	80 mM	0.0275 mL	0.1375 mL	0.2750 mL	0.6876 mL
	100 mM	0.0220 mL	0.1100 mL	0.2200 mL	0.5501 mL