Capeserod hydrochloride (Synonyms: SL65.0155)

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Capeserod hydrochloride (SL65.0155) is a 5-HT_4(e) receptor partial agonist (K_i=0.6 nM) with potent cognitive enhancing properties. Capeserod hydrochloride acts as a partial agonist in cells expressing 5-HT_4(b) and 5-HT_4(e) splice variants, stimulating cAMP production with IC₅₀ values ??of 244 and 29 nM, respectively. Capeserod hydrochloride is used in the study of memory impairment and dementia.

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Capeserod hydrochloride Chemical Structure

CAS No. : 191023-43-5

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Other Forms of Capeserod hydrochloride:

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

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Description

IC₅₀ & Target^[1]

5-HT_4(e) Receptor

0.6 nM (Ki)

Molecular Weight

493.38

Formula

C₂₃H₂₆Cl₂N₄O₄

CAS No.

191023-43-5

SMILES

O=C1OC(C2=C3OCCOC3=C(N)C(Cl)=C2)=NN1C4CCN(CC4)CCC5=CC=CC=C5.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Moser P C, et al. SL65. 0155, a novel 5-hydroxytryptamine4 receptor partial agonist with potent cognition-enhancing properties[J]. Journal of Pharmacology and Experimental Therapeutics, 2002, 302(2): 731-741. [Content Brief]

Capeserod hydrochloride Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Capeserod191023-43-5SL65.01555-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorCognitive enhancementpartial agonistsplice variantmemory deficitInhibitorinhibitorinhibit

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