2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Capeserod

Capeserod (SL65.0155 free base) is an agonist for serotonin receptor (5-HT receptor), with a Ki of 0.6 nM for 5-HT4 receptor. Capeserod enhances expression of phopshorilated cAMP-response element binding protein (p-CREB), vascular endothelium growth factor (VEGF), brain-derived neurotrophic factor (BDNF) and B cell lymphoma-2 (Bcl-2) proteins in hippocampus, and exhibits antidepressant-like efficacy in Wistar rats models.

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Capeserod Chemical Structure

Capeserod Chemical Structure

CAS No. : 769901-96-4

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Based on 1 publication(s) in Google Scholar

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Capeserod Related Antibodies

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Description

Capeserod (SL65.0155 free base) is an agonist for serotonin receptor (5-HT receptor), with a Ki of 0.6 nM for 5-HT4 receptor. Capeserod enhances expression of phopshorilated cAMP-response element binding protein (p-CREB), vascular endothelium growth factor (VEGF), brain-derived neurotrophic factor (BDNF) and B cell lymphoma-2 (Bcl-2) proteins in hippocampus, and exhibits antidepressant-like efficacy in Wistar rats models[1].

IC50 & Target

5-HT4 Receptor

0.6 nM (Ki)

Molecular Weight

456.92

Formula

C23H25ClN4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1OC(C2=C3OCCOC3=C(N)C(Cl)=C2)=NN1C4CCN(CC4)CCC5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Capeserod Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Capeserod769901-96-4SL65.01555-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorWistar ratsantidepressantclomipraminecitalopramInhibitorinhibitorinhibit

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