2. Membrane Transporter/Ion Channel Autophagy
  3. Sodium Channel Autophagy Mitophagy
  4. Carbamazepine-d10

Carbamazepine-d10  (Synonyms: CBZ-d10; NSC 169864-d10)

Cat. No.: HY-B0246S Purity: 99.24%
COA Handling Instructions

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Carbamazepine-d10 is the deuterium labeled Carbamazepine. Carbamazepine (CBZ), a sodium channel blocker, is an anticonvulsant agent[1][2].

For research use only. We do not sell to patients.

Carbamazepine-d<sub>10</sub> Chemical Structure

Carbamazepine-d10 Chemical Structure

CAS No. : 132183-78-9

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1 mg USD 210 In-stock
5 mg USD 620 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Carbamazepine-d10:

Carbamazepine-d10 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Carbamazepine-d10 is the deuterium labeled Carbamazepine. Carbamazepine (CBZ), a sodium channel blocker, is an anticonvulsant agent[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Carbamazepine-d10 Related Antibodies
Molecular Weight

246.33

Formula

C15H2D10N2O
CAS No.
Unlabeled CAS

298-46-4
Appearance

Solid

Color

White to off-white

SMILES

NC(N1C2=C([2H])C([2H])=C([2H])C([2H])=C2C([2H])=C([2H])C3=C([2H])C([2H])=C([2H])C([2H])=C31)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 25 mg/mL (101.49 mM)

DMSO : ≥ 25 mg/mL (101.49 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 25 mg/mL (101.49 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 25 mg/mL (101.49 mM)

Ethanol : ≥ 3 mg/mL (12.18 mM)

Ethanol : ≥ 3 mg/mL (12.18 mM)

DMSO:PBS (pH 7.2) (1:1) : ≥ 0.5 mg/mL (2.03 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0596 mL 20.2980 mL 40.5959 mL
5 mM 0.8119 mL 4.0596 mL 8.1192 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO:PBS (pH 7.2) (1:1) / Ethanol / Ethanol / DMF / DMSO / DMSO / DMF 1 mM 4.0596 mL 20.2980 mL 40.5959 mL 101.4899 mL
Ethanol / Ethanol / DMF / DMSO / DMSO / DMF 5 mM 0.8119 mL 4.0596 mL 8.1192 mL 20.2980 mL
10 mM 0.4060 mL 2.0298 mL 4.0596 mL 10.1490 mL
DMF / DMSO / DMSO / DMF 15 mM 0.2706 mL 1.3532 mL 2.7064 mL 6.7660 mL
20 mM 0.2030 mL 1.0149 mL 2.0298 mL 5.0745 mL
25 mM 0.1624 mL 0.8119 mL 1.6238 mL 4.0596 mL
30 mM 0.1353 mL 0.6766 mL 1.3532 mL 3.3830 mL
40 mM 0.1015 mL 0.5074 mL 1.0149 mL 2.5372 mL
50 mM 0.0812 mL 0.4060 mL 0.8119 mL 2.0298 mL
60 mM 0.0677 mL 0.3383 mL 0.6766 mL 1.6915 mL
80 mM 0.0507 mL 0.2537 mL 0.5074 mL 1.2686 mL
100 mM 0.0406 mL 0.2030 mL 0.4060 mL 1.0149 mL
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Carbamazepine-d10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carbamazepine-d10132183-78-9CBZ-d10NSC 169864-d10Sodium ChannelAutophagyMitophagyNa channelsNa+ channelsMitochondrial AutophagyInhibitorinhibitorinhibit

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