Carcinine dihydrochloride (Synonyms: β-Alanylhistamine dihydrochloride)

Cat. No.: HY-107567B Purity: 99.39%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Carcinine (β-Alanylhistamine) dihydrochloride is a selective histamine H3 antagonist with antioxidant activity and neuroprotective effects on the retina of oxidatively stressed mice.

For research use only. We do not sell to patients.

Carcinine dihydrochloride Chemical Structure

CAS No. : 57022-38-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of Carcinine dihydrochloride:

Carcinine Get quote

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Biological Activity
Purity & Documentation
References
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Description

Carcinine (β-Alanylhistamine) dihydrochloride is a selective histamine H3 antagonist with antioxidant activity and neuroprotective effects on the retina of oxidatively stressed mice^[1]^[2].

Molecular Weight

255.14

Formula

C₈H₁₆Cl₂N₄O

CAS No.

57022-38-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCC1=CN=CN1)CCN.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 175 mg/mL (685.90 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9194 mL	19.5971 mL	39.1942 mL
5 mM	0.7839 mL	3.9194 mL	7.8388 mL
10 mM	0.3919 mL	1.9597 mL	3.9194 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.39%

Select Batch:

Data Sheet (266 KB) SDS (615 KB)

COA (243 KB) HNMR (245 KB) LCMS (86 KB)

Handling Instructions (2659 KB)

References

[1]. Zhong Chen, et al. Pharmacological effects of carcinine on histaminergic neurons in the brain. Br J Pharmacol. 2004 Nov;143(5):573-80. [Content Brief]

[2]. Lea D Marchette, et al. Carcinine has 4-hydroxynonenal scavenging property and neuroprotective effect in mouse retina. Invest Ophthalmol Vis Sci. 2012 Jun 20;53(7):3572-83. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.9194 mL	19.5971 mL	39.1942 mL	97.9854 mL
	5 mM	0.7839 mL	3.9194 mL	7.8388 mL	19.5971 mL
	10 mM	0.3919 mL	1.9597 mL	3.9194 mL	9.7985 mL
	15 mM	0.2613 mL	1.3065 mL	2.6129 mL	6.5324 mL
	20 mM	0.1960 mL	0.9799 mL	1.9597 mL	4.8993 mL
	25 mM	0.1568 mL	0.7839 mL	1.5678 mL	3.9194 mL
	30 mM	0.1306 mL	0.6532 mL	1.3065 mL	3.2662 mL
	40 mM	0.0980 mL	0.4899 mL	0.9799 mL	2.4496 mL
	50 mM	0.0784 mL	0.3919 mL	0.7839 mL	1.9597 mL
	60 mM	0.0653 mL	0.3266 mL	0.6532 mL	1.6331 mL
	80 mM	0.0490 mL	0.2450 mL	0.4899 mL	1.2248 mL
	100 mM	0.0392 mL	0.1960 mL	0.3919 mL	0.9799 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Carcinine dihydrochloride Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carcinine57022-38-5β-AlanylhistamineHistamine ReceptorInhibitorinhibitorinhibit

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