2. Others Cell Cycle/DNA Damage
  3. Isotope-Labeled Compounds DNA Alkylator/Crosslinker
  4. Carmustine-d8

Carmustine-d8 is the deuterium labeled Carmustine. Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA[1][2].

For research use only. We do not sell to patients.

Carmustine-d<sub>8</sub> Chemical Structure

Carmustine-d8 Chemical Structure

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1 mg USD 150 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Carmustine-d8:

Carmustine-d8 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Carmustine-d8 is the deuterium labeled Carmustine. Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Carmustine-d8 Related Antibodies
Molecular Weight

222.10

Formula

C5HD8Cl2N3O2
Unlabeled CAS

154-93-8
Appearance

Solid-Liquid Mixture

Color

Colorless to off-white

SMILES

[2H]C(Cl)(C([2H])(NC(N(C([2H])(C([2H])(Cl)[2H])[2H])N=O)=O)[2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (450.25 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5025 mL 22.5124 mL 45.0248 mL
5 mM 0.9005 mL 4.5025 mL 9.0050 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.34%

SDS (251 KB)

COA (251 KB) HNMR (494 KB) RP-HPLC (809 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.5025 mL 22.5124 mL 45.0248 mL 112.5619 mL
5 mM 0.9005 mL 4.5025 mL 9.0050 mL 22.5124 mL
10 mM 0.4502 mL 2.2512 mL 4.5025 mL 11.2562 mL
15 mM 0.3002 mL 1.5008 mL 3.0017 mL 7.5041 mL
20 mM 0.2251 mL 1.1256 mL 2.2512 mL 5.6281 mL
25 mM 0.1801 mL 0.9005 mL 1.8010 mL 4.5025 mL
30 mM 0.1501 mL 0.7504 mL 1.5008 mL 3.7521 mL
40 mM 0.1126 mL 0.5628 mL 1.1256 mL 2.8140 mL
50 mM 0.0900 mL 0.4502 mL 0.9005 mL 2.2512 mL
60 mM 0.0750 mL 0.3752 mL 0.7504 mL 1.8760 mL
80 mM 0.0563 mL 0.2814 mL 0.5628 mL 1.4070 mL
100 mM 0.0450 mL 0.2251 mL 0.4502 mL 1.1256 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Carmustine-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carmustine-d8Isotope-Labeled CompoundsDNA Alkylator/CrosslinkerInhibitorinhibitorinhibit

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