2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. 101982-51-8

101982-51-8

NSC 80467 Chemical Structure

101982-51-8

Chemical Structure

  • NSC 80467
  • CAS No: 101982-51-8
    Formula: C24H22BrN3O5
    Molecular Weight: 512.35
  • IUPAC Name: 1-isobutyl-2-methyl-3-(2-(4-nitrophenyl)-2-oxoethyl)-4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide
  • InChIKey: SDVDJIZVNFVMLG-UHFFFAOYSA-M
  • SMILES: O=C(C1=C2[N+](CC(C3=CC=C([N+]([O-])=O)C=C3)=O)=C(C)N1CC(C)C)C4=C(C=CC=C4)C2=O.[Br-]

Biological Activity: NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage[1].

Cat. No. Product Name Purity Description
HY-137843 NSC 80467 98.04% NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage.

References

[1]. Glaros TG, et al. The "survivin suppressants" NSC 80467 and YM155 induce a DNA damage response [published correction appears in Cancer Chemother Pharmacol. 2012 Nov;70(5):763-4]. Cancer Chemother Pharmacol. 2012;70(1):207-212. [Content Brief]

Keywords:

NSC 80467