2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. NSC 80467

NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage.

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NSC 80467 Chemical Structure

NSC 80467 Chemical Structure

CAS No. : 101982-51-8

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Based on 1 publication(s) in Google Scholar

NSC 80467 Related Antibodies

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Description

NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage[1].

In Vitro

NSC 80467 has a similar spectrum of activity against the NCI-60 cell line panel, suppresses survivin expression, shows COMPARE correlation with DNA damaging agents, preferentially inhibits DNA synthesis, and induces a DNA damage response characterized by enhanced γH2AX and pKAP1 at concentrations lower than those capable of inhibiting survivin expression[1].
NSC 80467 (200 or 800 nM; 24 hours) inhibits surviving[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC 80467 Related Antibodies

Western Blot Analysis[1]

Cell Line: PC3 cells
Concentration: 200 or 800 nM
Incubation Time: 24 hours
Result: Associated with inhibition of survivin expression.
Molecular Weight

512.35

Formula

C24H22BrN3O5
CAS No.
Appearance

Solid

Color

Gray to brown

SMILES

O=C(C1=C2[N+](CC(C3=CC=C([N+]([O-])=O)C=C3)=O)=C(C)N1CC(C)C)C4=C(C=CC=C4)C2=O.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (48.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9518 mL 9.7590 mL 19.5179 mL
5 mM 0.3904 mL 1.9518 mL 3.9036 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9518 mL 9.7590 mL 19.5179 mL 48.7948 mL
5 mM 0.3904 mL 1.9518 mL 3.9036 mL 9.7590 mL
10 mM 0.1952 mL 0.9759 mL 1.9518 mL 4.8795 mL
15 mM 0.1301 mL 0.6506 mL 1.3012 mL 3.2530 mL
20 mM 0.0976 mL 0.4879 mL 0.9759 mL 2.4397 mL
25 mM 0.0781 mL 0.3904 mL 0.7807 mL 1.9518 mL
30 mM 0.0651 mL 0.3253 mL 0.6506 mL 1.6265 mL
40 mM 0.0488 mL 0.2440 mL 0.4879 mL 1.2199 mL
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NSC 80467 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC 80467101982-51-8NSC80467NSC-80467DNA/RNA SynthesisDNA damaging synthesis,γH2AXpKAP1NCI-60cellPC3Inhibitorinhibitorinhibit

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