2. Natural Products
  3. Disease Research Fields Plants Others
  4. Other Diseases Meliaceae
  5. Swietenia mahagoni (L.) Jacq.
  6. 2077980-80-2

2077980-80-2

GLL398 Chemical Structure

2077980-80-2

Chemical Structure

  • GLL398
  • CAS No: 2077980-80-2
    Formula: C25H23BO4
    Molecular Weight: 398.26
  • IUPAC Name: (2E)-3-(4-(1-(4-boronophenyl)-2-phenylbut-1-en-1-yl)phenyl)acrylic acid
  • InChIKey: BINZFDGAOTWQNC-YGCRUXFTSA-N
  • SMILES: OC(/C=C/C(C=C1)=CC=C1/C(C2=CC=C(B(O)O)C=C2)=C(C3=CC=CC=C3)/CC)=O

Biological Activity: GLL398 is a potent, orally bioavailable selective estrogen receptor degrader (SERD) with an IC50 value of 1.14 nM. GLL398 shows a strong dose-dependent binding to ER with a mutation at Y537S (IC50=29.5 nM). GLL398 blocks tumor growth in xenograft models of breast cancer.

Cat. No. Product Name Purity Description
HY-101119 GLL398 GLL398 is a potent, orally bioavailable selective estrogen receptor degrader (SERD) with an IC50 value of 1.14 nM. GLL398 shows a strong dose-dependent binding to ER with a mutation at Y537S (IC50=29.5 nM). GLL398 blocks tumor growth in xenograft models of breast cancer.

Keywords:

GLL398