GLL398

Cat. No.: HY-101119: FAQs
Data Sheet Handling Instructions

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GLL398 is a potent, orally bioavailable selective estrogen receptor degrader (SERD) with an IC₅₀ value of 1.14 nM. GLL398 shows a strong dose-dependent binding to ER with a mutation at Y537S (IC₅₀=29.5 nM). GLL398 blocks tumor growth in xenograft models of breast cancer.

For research use only. We do not sell to patients.

GLL398 Chemical Structure

CAS No. : 2077980-80-2

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250 mg		Get quote
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•Related Small Molecules:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

GLL398 is a boron-modified GW5638 analog^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

398.26

Formula

C₂₅H₂₃BO₄

CAS No.

2077980-80-2

SMILES

OC(/C=C/C(C=C1)=CC=C1/C(C2=CC=C(B(O)O)C=C2)=C(C3=CC=CC=C3)/CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (627.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5109 mL	12.5546 mL	25.1092 mL
5 mM	0.5022 mL	2.5109 mL	5.0218 mL
10 mM	0.2511 mL	1.2555 mL	2.5109 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Guo S, et al. GLL398, an oral selective estrogen receptor degrader (SERD), blocks tumor growth in xenograft breast cancer models. Breast Cancer Res Treat. 2020;180(2):359-368. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5109 mL	12.5546 mL	25.1092 mL	62.7731 mL
	5 mM	0.5022 mL	2.5109 mL	5.0218 mL	12.5546 mL
	10 mM	0.2511 mL	1.2555 mL	2.5109 mL	6.2773 mL
	15 mM	0.1674 mL	0.8370 mL	1.6739 mL	4.1849 mL
	20 mM	0.1255 mL	0.6277 mL	1.2555 mL	3.1387 mL
	25 mM	0.1004 mL	0.5022 mL	1.0044 mL	2.5109 mL
	30 mM	0.0837 mL	0.4185 mL	0.8370 mL	2.0924 mL
	40 mM	0.0628 mL	0.3139 mL	0.6277 mL	1.5693 mL
	50 mM	0.0502 mL	0.2511 mL	0.5022 mL	1.2555 mL
	60 mM	0.0418 mL	0.2092 mL	0.4185 mL	1.0462 mL
	80 mM	0.0314 mL	0.1569 mL	0.3139 mL	0.7847 mL
	100 mM	0.0251 mL	0.1255 mL	0.2511 mL	0.6277 mL

GLL398 Related Classifications

Cancer

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GLL3982077980-80-2GLL 398GLL-398Estrogen Receptor/ERRselective estrogen receptor degraderSERDbreast cancermutantESR1 Y537SInhibitorinhibitorinhibit

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