2. GPCR/G Protein Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Leukotriene Receptor PPAR Cytochrome P450
  4. 120128-20-3

120128-20-3

RG-12525 Chemical Structure

120128-20-3

Chemical Structure

  • RG-12525
  • Synonym(s): NID 525
  • CAS No: 120128-20-3
    Formula: C25H21N5O2
    Molecular Weight: 423.47
  • IUPAC Name: 2-((4-((2-((1H-tetrazol-5-yl)methyl)benzyl)oxy)phenoxy)methyl)quinoline
  • InChIKey: JELDFLOBXROBFH-UHFFFAOYSA-N
  • SMILES: C1(COC2=CC=C(OCC3=CC=CC=C3CC4=NN=NN4)C=C2)=NC5=CC=CC=C5C=C1

Biological Activity: RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC50s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC50 of appr 60 nM and a potent inhibitor of CYP3A4, with a Ki value of 0.5 µM.

Cat. No. Product Name Purity Description
HY-101676 RG-12525 98.31% RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC50s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC50 of appr 60 nM and a potent inhibitor of CYP3A4, with a Ki value of 0.5 µM.

Keywords:

RG-12525