2. Anti-infection
  3. Antibiotic
  4. 68489-09-8

68489-09-8

Acoltremon Chemical Structure

68489-09-8

Chemical Structure

  • Acoltremon
  • Synonym(s): WS-12; AR-15512; AVX-012
  • CAS No: 68489-09-8
    Formula: C18H27NO2
    Molecular Weight: 289.41
  • IUPAC Name: (1R,2S,5R)-2-isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide
  • InChIKey: HNSGVPAAXJJOPQ-XOKHGSTOSA-N
  • SMILES: O=C([C@H]1[C@H](C(C)C)CC[C@@H](C)C1)NC2=CC=C(OC)C=C2

Biological Activity: Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research[1][2].

Cat. No. Product Name Purity Description
HY-108449 Acoltremon 99.13% Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research.

References

[1]. Beck B, et al. Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium. 2007 Mar;41(3):285-94. [Content Brief]
[2]. Ma S, et al. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. Pak J Pharm Sci. 2008 Oct;21(4):370-8. [Content Brief]

Keywords:

Acoltremon